151360-57-5

Basic information

• Product Name: Methyl 2-chloro-6-fluorobenzoate
• Synonyms: Methyl 2-chloro-6-fluorobenzoate
• CAS NO: 151360-57-5
• Molecular Formula: C8H6ClFO2
• Molecular Weight: 188.5834432
• Mol File: 151360-57-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 234.4°C at 760 mmHg
• Flash Point: 99.9°C
• Appearance: /
• Density: 1.314g/cm³
• Vapor Pressure: 0.053mmHg at 25°C
• Refractive Index: 1.51
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Methyl 2-chloro-6-fluorobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-chloro-6-fluorobenzoate(151360-57-5)
• EPA Substance Registry System: Methyl 2-chloro-6-fluorobenzoate(151360-57-5)

Safety Data

• Hazardous Substances Data: 151360-57-5(Hazardous Substances Data)

Usage

General Description

Methyl 2-chloro-6-fluorobenzoate is a chemical compound with the molecular formula C8H6ClFO2. It has a molar mass of 186.58 g/mol. Methyl 2-chloro-6-fluorobenzoate is a white solid with a molecular weight of 186.59. It is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Methyl 2-chloro-6-fluorobenzoate is also used in the production of dyes and other organic compounds. It is important to handle this compound with caution as it may be harmful if swallowed, inhaled, or in contact with skin.

InChI:InChI=1/C8H6ClFO2/c1-12-8(11)7-5(9)3-2-4-6(7)10/h2-4H,1H3

Upstream product

• 67-56-1 methanol 
• 434-75-3 2-chloro-6-fluorobenzoic acid 
• 625-98-9 3-chlorofluorobenzene 
• 79-22-1 methyl chloroformate 
• 60-29-7 diethyl ether 

Downstream Products

• 267881-03-8 3-(2-chloro-6-fluorophenyl)-3-oxopropanenitrile 
• 1241677-49-5 2-(2-chloro-6-fluorophenyl)pyrrolidine 

Relevant articles and documents

New pyrazole derivatives as CRAC channel modulators

The present invention relates to compounds of formula (I) which are inhibitors of CRAC channel activity. This invention also relates to pharmaceutical compositions containing them, process for their preparation and their use in therapy.

Heterocyclic compounds and methods of use

The present invention comprises a new class of compounds capable of modulating the c-kit protein kinase and, accordingly, useful for treatment of c-kit mediated diseases including, without limitation, autoimmune disease, allergies, mastcytosis, mast cell related tumors and various fibrotic diseases. The compounds have a general Formula I wherein R1-5, X, Y and Z are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of c-kit mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.

Method for preparing aromatic compounds

A method for synthesizing aromatic compounds by selectively dehalogenating aromatic starting materials is provided. Compounds may be prepared which are substituted with fluoro, chloro or bromo. The method may be used to remove halogen atoms from sites at which halogenation is not desired, and to form substantially pure halogenated compounds from mixtures of starting materials. The method uses a copper containing dehalogenation agent and an acid with the dehalogenation being controlled by a substituent such as a carboxylic acid, amide, ester, aldehyde, ketone or cyano on the aromatic ring.