1514-16-5

Usage

Fluorenone derivative

Contains a fluorene ring system with a ketone and a fluorine atom attached to it.

Fluorinating agent

Commonly used in organic synthesis to introduce a fluorine atom into organic molecules.

Reactions

Participates in reactions such as the Hiyama coupling.

Precursor

Used as a precursor for the synthesis of various fluorinated compounds.

Applications

Pharmaceutical and agrochemical industries.

Development

Valuable tool in the development of new fluorine-containing compounds.

Fields of application

Medicine, materials science, and industry.

Upstream product

• 1072-85-1 o-fluorobromobenzene 
• 85-44-9 phthalic anhydride 
• 1841-56-1 3-fluoro-[1,1'-biphenyl]-2-carboxylic acid 

Downstream Products

• 36323-52-1 1-Fluor-9-fluorenol 
• 2094-03-3 3'-fluoro-[1,1'-biphenyl]-2-carboxylic acid 
• 3825-98-7 8-Fluor-2-nitro-9-oxo-fluoren 
• 6967-22-2 9-Brom-1-fluorfluoren 

Relevant academic research and scientific papers

Synthesis of fluorenones through rhodium-catalyzed intramolecular acylation of biarylcarboxylic acids

An efficient approach to the synthesis of fluorenones via the rhodium-catalyzed intramolecular acylation of biarylcarboxylic acids was developed. Using this procedure, fluorenones with various substituents can be synthesized in good to high yields. This work marks the first recorded use of catalytic intramolecular acylation to synthesize fluorenones.

Decarboxylative C-H arylation of benzoic acids under radical conditions

A decarboxylative radical cyclization reaction has been developed for the synthesis of fluorenones. The reaction uses Ag(I)/K2S 2O8 to oxidatively decarboxylate an aroylbenzoic acid to an aryl radical, which undergoes cyclization to afford fluorenone products in good yield.