1514-26-7

Usage

Uses

Used in Organic Synthesis:
M-(4-FLUOROPHENOXY)TOLUENE is used as a reagent in organic synthesis for its ability to participate in aromatic substitution reactions, contributing to the formation of more complex chemical structures.
Used in Chemical Research:
In the field of chemical research, M-(4-FLUOROPHENOXY)TOLUENE is used as a precursor to explore the properties and reactions of fluorinated compounds, furthering our understanding of fluorine chemistry and its applications.
Used in Pharmaceutical Industry:
M-(4-FLUOROPHENOXY)TOLUENE is used as an intermediate in the synthesis of pharmaceutical compounds, where its fluorine atom may impart specific properties to the final drug product, such as increased lipophilicity or altered metabolic stability.
Used in Material Science:
In material science, M-(4-FLUOROPHENOXY)TOLUENE is used as a building block for the development of new materials with tailored properties, such as improved thermal stability or enhanced electronic characteristics, due to the presence of the fluorine atom.

Upstream product

• 371-41-5 4-Fluorophenol 
• 591-17-3 meta-bromotoluene 
• 108-39-4 3-methyl-phenol 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 352-34-1 4-fluoro-1-iodobenzene 

Downstream Products

• 371-41-5 4-Fluorophenol 

Relevant academic research and scientific papers

Evaluation of fluorinated biphenyl ether pro-drug scaffolds employing the chemical-microbial approach

Incorporation of fluorine in a drug can dramatically affect its metabolism and methods to assess the effect of fluorine substitution on drug metabolism are required for effective drug design. Employing a previously developed chemical-microbial method the metabolism of a series of fluorinated biphenyl ethers was determined. The substrates were synthesized via Ullmann-type condensation reactions between bromotoluene and fluorophenol. The ethers were incubated with the fungus Cunninghamella elegans, which oxidises xenobiotics in an analogous fashion to mammals, generating a number of hydroxylated biphenyl ethers and acids. The propensity of the fluorinated ring to be hydroxylated depended upon the position of the fluorine atom, and the oxidation of the methyl group was observed when it was meta to the oxygen. The experiments demonstrate the applicability of the method to rapidly determine the effect of fluorine substitution on CYP-catalysed biotransformation of pro-drug molecules.

Low catalyst loadings for copper-catalyzed O-arylation of phenols with aryl and heteroaryl halides under mild conditions

A practical and mild strategy has been developed for the cross-coupling of O-arylation of phenol with differently substituted aryl halides and heteroaryl iodides using low catalyst loading of copper iodide under low operating temperature in DMF with TMHD as the ligand and Cs2CO3 as the base. This method tolerates a variety of functional groups including sterically hindered phenols and heteroaryl iodides to afford products in good to excellent yields (up to 95%). Georg Thieme Verlag Stuttgart. New York.

N-[1-(3-phenoxyphenyl)ethyl]acetohydroxamic acid compounds which are useful anti-inflammatory agents

The present invention provides compounds of formula (II) STR1 wherein q is 1, and p is 1; Ar is phenyl optionally substituted by one or more substitutents independently selected from C1-4 alkyl (which may be substituted by one or more halogen a

Anti-inflammatory aryl derivatives

The present inventions concerned with compounds of formula (I) wherein, Ar is 4-halophenyl;, Ar? is 1,3- or 1,4-phenylene;, Y is (E)-CH=CH-; and, R1 and R2 are independently selected from hydrogen and C1-4alkyl;, and base salts and physiologica