1514-82-5

Basic information

• Product Name: 2-BROMO-3,3,3-TRIFLUOROPROPENE
• Synonyms: 2-BROMO-3,3,3-TRIFLUORO-1-PROPENE;2-BROMO-3,3,3-TRIFLUOROPROP-1-ENE;2-BROMO-3,3,3-TRIFLUOROPROPENE;2-Bromo-3,3,3-Trifluoropropane;2-Bromo-3,3,3-trifluoroprop-1-ene 98%;2-Bromo-3,3,3-trifluoroprop-1-ene98%;2-BROMO-3,3,3-TRIFLUOROPROPENE, 98+%;2-Bromo-3,3,3-trifluoro-1-propene (stabilized with Copper chip)
• CAS NO: 1514-82-5
• Molecular Formula: C₃H₂BrF₃
• Molecular Weight: 174.95
• EINECS: -0
• Product Categories: Fluorinated Building Blocks;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;Synthetic Organic Chemistry;Alkenyl;Halogenated Hydrocarbons;Organic Building Blocks
• Mol File: 1514-82-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 29-30 °C(lit.)
• Flash Point: ~−10 °F
• Appearance: Clear colorless/Liquid
• Density: 1.686
• Vapor Pressure: 341mmHg at 25°C
• Refractive Index: n20/D 1.3550(lit.)
• Storage Temp.: Refrigerator
• Water Solubility: Soluble in most organic solvents, immiscible with water.
• Stability: Stable, but extremely flammable. Incompatible with strong oxidizing agents.
• CAS DataBase Reference: 2-BROMO-3,3,3-TRIFLUOROPROPENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-3,3,3-TRIFLUOROPROPENE(1514-82-5)
• EPA Substance Registry System: 2-BROMO-3,3,3-TRIFLUOROPROPENE(1514-82-5)

Safety Data

• Hazard Codes: F+,F,Xi
• Statements: 12-66
• Safety Statements: 24-36
• RIDADR: UN 1993 3/PG 1
• WGK Germany: 3
• HazardClass: IRRITANT, GAS
• PackingGroup: I
• Hazardous Substances Data: 1514-82-5(Hazardous Substances Data)

Usage

Chemical Properties

liquid

Uses

It is used as intermediate in production of organ fluorine compounds & as a monomer in fluoropolymer production. It is used as a trifluoromethylated synthetic building block for the synthesis of trifluoromethyl-substituted molecules.

General Description

2-Bromo-3,3,3-trifluoro-1-propene can be added to N2 gas in order to enhance its fire suppression efficiency.

InChI:InChI=1S/C3H2BrF3/c1-2(4)3(5,6)7/h1H2

Synthetic route

1,2-Dibromo-3,3,3-trifluoropropane (431-21-0) → 2-bromo-3,3,3-trifluoropropene (1514-82-5)

Conditions	Yield
With potassium hydroxide	93%
With potassium hydroxide In ethanol at -10℃;	91%
With Aliquat 336; sodium hydroxide at 50 - 70℃;	80.46%

2,3-dibromo-3,3-difluoro-propene (677-35-0) → 2-bromo-3,3,3-trifluoropropene (1514-82-5)

Conditions	Yield
With antimonypentachloride; antimony(III) fluoride

3-acetoxy-2-bromo-1,1,1-trifluoropropane (383-68-6) → 2-bromo-3,3,3-trifluoropropene (1514-82-5)

Conditions	Yield
With potassium hydroxide

(2-bromo-3,3,3-trifluoro-propyl)-bis-trifluoromethyl-amine (19451-92-4) → 2-bromo-3,3,3-trifluoropropene (1514-82-5)

Conditions	Yield
With potassium hydroxide

2-bromo-3-chloro-3,3-difluoro-propene (421-44-3) + antimony(III) fluoride (7783-56-4) + 1,2-dichloro-ethane (107-06-2) + antimony dichloride trifluoride → 2-bromo-3,3,3-trifluoropropene (1514-82-5)

2-bromo-3,3,3-trichloro-propene (28124-18-7) + antimony(III) fluoride (7783-56-4) + 1,2-dichloro-ethane (107-06-2) + antimony dichloride trifluoride → 2-bromo-3,3,3-trifluoropropene (1514-82-5)

1,2-Dibromo-3,3,3-trifluoropropane (431-21-0) + ethanolic KOH-solution → 3,3,3-trifluoroprop-1-yne (661-54-1) + 2-bromo-3,3,3-trifluoropropene (1514-82-5)

Conditions	Yield
at -5℃;

1,2-Dibromo-3,3,3-trifluoropropane (431-21-0) + potassium hydroxide → 3,3,3-trifluoroprop-1-yne (661-54-1) + 2-bromo-3,3,3-trifluoropropene (1514-82-5)

3-acetoxy-2-bromo-1,1,1-trifluoropropane (383-68-6) → 1,1,1-trifluoro-2,3-epoxypropane (359-41-1) + 2-bromo-3,3,3-trifluoropropene (1514-82-5)

Conditions	Yield
With sodium hydroxide In water at 100℃; Title compound not separated from byproducts.;

2-bromo-1,1,1-trifluoropropan-3-ol (311-86-4) → 1,1,1-trifluoro-2,3-epoxypropane (359-41-1) + 2-bromo-3,3,3-trifluoropropene (1514-82-5)

Conditions	Yield
With sodium hydroxide In water at 0 - 95℃;

2-bromo-3,3,3-trifluoropropene (1514-82-5) + cyclohexanecarbaldehyde (2043-61-0) → 1-Cyclohexyl-4,4,4-trifluoro-2-butyn-1-ol (95540-90-2)

Conditions	Yield
Stage #1: 2-bromo-3,3,3-trifluoropropene With n-butyllithium; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; hexane at -78℃; for 0.333333h; Inert atmosphere; Stage #2: cyclohexanecarbaldehyde In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere;	100%
With lithium diisopropyl amide In tetrahydrofuran 1.) -78 deg C, 5 min, 2.) 30 min;	93.3%
With lithium diisopropyl amide In tetrahydrofuran; cyclohexane 1.) -78 deg C, 10 min, 2.) -78 deg C, 1 h;	90%

heptanal (111-71-7) + 2-bromo-3,3,3-trifluoropropene (1514-82-5) → 1,1,1-trifluoro-2-decyn-4-ol (94792-94-6)

Conditions	Yield
Stage #1: 2-bromo-3,3,3-trifluoropropene With n-butyllithium; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; hexane at -78℃; for 0.333333h; Inert atmosphere; Stage #2: heptanal In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere;	100%
With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.5h;	90%
With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 3h;

(E)-3-phenylpropenal (14371-10-9) + 2-bromo-3,3,3-trifluoropropene (1514-82-5) → (E)-6,6,6-Trifluoro-1-phenyl-1-hexen-4-yn-3-ol (171668-24-9)

Conditions	Yield
With lithium diisopropyl amide In tetrahydrofuran 1.) -78 deg C, 5 min, 2.) 30 min;	99%

3-phenyl-propionaldehyde (104-53-0) + 2-bromo-3,3,3-trifluoropropene (1514-82-5) → 6,6,6-Trifluoro-1-phenyl-4-hexyn-3-ol (94792-93-5)

Conditions	Yield
With lithium diisopropyl amide In tetrahydrofuran 1.) -78 deg C, 5 min, 2.) 30 min;	99%
With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.5h;	99%
Stage #1: 2-bromo-3,3,3-trifluoropropene With lithium diisopropyl amide In tetrahydrofuran; hexane at -80℃; for 0.0833333h; Stage #2: 3-phenyl-propionaldehyde In tetrahydrofuran; hexane at -80℃; for 1.5h;	89%
Stage #1: 2-bromo-3,3,3-trifluoropropene With n-butyllithium; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; hexane at -78℃; for 0.333333h; Inert atmosphere; Stage #2: 3-phenyl-propionaldehyde In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere;	80%

2-bromo-3,3,3-trifluoropropene (1514-82-5) + cyclohexanone (108-94-1) → 1-(3,3,3-trifluoro-1-propynyl)-1-cyclohexanol (96302-93-1)

Conditions	Yield
With lithium diisopropyl amide In tetrahydrofuran 1.) -78 deg C, 5 min, 2.) 30 min;	99%
Stage #1: 2-bromo-3,3,3-trifluoropropene With n-butyllithium; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; hexane at -78℃; for 0.333333h; Inert atmosphere; Stage #2: cyclohexanone In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere;	96%
Stage #1: 2-bromo-3,3,3-trifluoropropene With lithium diisopropyl amide In tetrahydrofuran; hexane; cyclohexane at -78 - 20℃; Stage #2: cyclohexanone In tetrahydrofuran; hexane; cyclohexane at -78℃; for 1h;	94%
Stage #1: 2-bromo-3,3,3-trifluoropropene With lithium hexamethyldisilazane In tetrahydrofuran at -78 - 0℃; Stage #2: cyclohexanone In tetrahydrofuran at 0℃;	90%

2-bromo-3,3,3-trifluoropropene (1514-82-5) + 4-tolyl iodide (624-31-7) → 1-(p-methylphenyl)-3,3,3-trifluoropropyne (82203-82-5)

Conditions	Yield
Stage #1: 2-bromo-3,3,3-trifluoropropene With dichloro(N,N,N’,N‘-tetramethylethylenediamine)zinc; lithium diisopropyl amide In tetrahydrofuran; hexane at -78 - 20℃; for 1h; Stage #2: 4-tolyl iodide With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran; hexane for 6h; Heating;	99%

2-bromo-3,3,3-trifluoropropene (1514-82-5) + para-iodoanisole (696-62-8) → 1-(p-methoxyphenyl)-3,3,3-trifluoropropyne (82203-83-6)

Conditions	Yield
Stage #1: 2-bromo-3,3,3-trifluoropropene With dichloro(N,N,N’,N‘-tetramethylethylenediamine)zinc; lithium diisopropyl amide In tetrahydrofuran; hexane at -78 - 20℃; for 1h; Stage #2: para-iodoanisole With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran; hexane for 6h; Heating;	99%

2-Ethylbutyraldehyde (97-96-1) + 2-bromo-3,3,3-trifluoropropene (1514-82-5) → 5-ethyl-1,1,1-trifluoro-2-heptyn-4-ol (1147879-99-9)

Conditions	Yield
Stage #1: 2-bromo-3,3,3-trifluoropropene With n-butyllithium; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; hexane at -78℃; for 0.333333h; Inert atmosphere; Stage #2: 2-Ethylbutyraldehyde In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere;	99%

2-bromo-3,3,3-trifluoropropene (1514-82-5) + benzaldehyde (100-52-7) → 1-phenyl-4,4,4-trifluorobut-2-yn-1-ol (149846-93-5, 128746-89-4)

Conditions	Yield
With lithium diisopropyl amide In tetrahydrofuran 1.) -78 deg C, 5 min, 2.) 30 min;	98.9%
With lithium diisopropyl amide In tetrahydrofuran; cyclohexane 1.) -78 deg C, 10 min, 2.) -78 deg C, 1 h;	95%
Stage #1: 2-bromo-3,3,3-trifluoropropene With lithium diisopropyl amide In tetrahydrofuran; hexane; cyclohexane at -78 - 20℃; Stage #2: benzaldehyde In tetrahydrofuran; hexane; cyclohexane at -78℃; for 1h;	93%

benzophenone (119-61-9) + 2-bromo-3,3,3-trifluoropropene (1514-82-5) → 1,1-Diphenyl-4,4,4-trifluorobut-2-yn-1-ol (186143-62-4)

Conditions	Yield
With lithium diisopropyl amide In tetrahydrofuran; cyclohexane 1.) -78 deg C, 10 min, 2.) -78 deg C, 1 h;	98%
Stage #1: 2-bromo-3,3,3-trifluoropropene With lithium diisopropyl amide In tetrahydrofuran; hexane; cyclohexane at -78 - 20℃; Stage #2: benzophenone In tetrahydrofuran; hexane; cyclohexane at -78℃; for 1h;	94%

2-bromo-3,3,3-trifluoropropene (1514-82-5) + tridecanal (10486-19-8) → 1,1,1-trifluoro-2-hexadecyn-4-ol

Conditions	Yield
Stage #1: 2-bromo-3,3,3-trifluoropropene With lithium diisopropyl amide In tetrahydrofuran; hexane at -80℃; for 0.0833333h; Stage #2: tridecanal In tetrahydrofuran; hexane at -80℃; for 1.5h;	98%

2-bromo-3,3,3-trifluoropropene (1514-82-5) + N-phenylbenzohydrazonoyl chloride (15424-14-3) → 1,3-diphenyl-5-(trifluoromethyl)-1H-pyrazole

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane In 5,5-dimethyl-1,3-cyclohexadiene at 20℃; for 24h; Reagent/catalyst; Solvent; regioselective reaction;	98%
With 1,4-diaza-bicyclo[2.2.2]octane In 5,5-dimethyl-1,3-cyclohexadiene at 20℃; for 24h; Reagent/catalyst; Solvent;	98%

2-bromo-3,3,3-trifluoropropene (1514-82-5) + (3,5-dichlorophenyl)boronic acid (67492-50-6) → 1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene (864725-22-4)

Conditions	Yield
With potassium carbonate; (1,4-naphthoquinone)-[1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene]palladium(0) In 1,4-dioxane; water at 90℃; for 5h; Product distribution / selectivity; Inert atmosphere;	97.8%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In tetrahydrofuran; water at 70℃; for 4h; Sealed tube;	85%
With potassium carbonate; bis-triphenylphosphine-palladium(II) chloride In tetrahydrofuran; water at 0 - 90℃; for 6h; Sealed tube;	83%

2-bromo-3,3,3-trifluoropropene (1514-82-5) + N-benzylidenebenzamide (10374-29-5) → N-[1-phenyl-2-(trifluoromethyl)prop-2-ene-1-yl]benzamide

Conditions	Yield
Stage #1: 2-bromo-3,3,3-trifluoropropene With sec.-butyllithium In diethyl ether; cyclohexane at -105℃; for 0.166667h; Stage #2: N-benzylidenebenzamide In diethyl ether; cyclohexane at -105 - -50℃; for 2h;	97%
Stage #1: 2-bromo-3,3,3-trifluoropropene; N-benzylidenebenzamide With sec.-butyllithium In diethyl ether; cyclohexane at -105℃; for 0.166667h; Inert atmosphere; Stage #2: With boron trifluoride diethyl etherate In diethyl ether; cyclohexane at -105 - -50℃; for 2h; Inert atmosphere; Stage #3: With water In diethyl ether; cyclohexane pH=7; aq. phosphate buffer;	97%

2-bromo-3,3,3-trifluoropropene (1514-82-5) + 2-Phenylpropanal (34713-70-7) → 6,6,6-Trifluoro-2-phenyl-4-hexyn-3-ol

Conditions	Yield
With lithium diisopropyl amide In tetrahydrofuran 1.) -78 deg C, 5 min, 2.) 30 min;	96.5%

iodobenzene (591-50-4) + 2-bromo-3,3,3-trifluoropropene (1514-82-5) → 3,3,3-trifluoro-2-phenylpropene (384-64-5)

Conditions	Yield
With chloro-trimethyl-silane; N,N,N,N,-tetramethylethylenediamine; silver; zinc In tetrahydrofuran multistep reaction; other aryl halides;	96%
With chloro-trimethyl-silane; N,N,N,N,-tetramethylethylenediamine; silver; zinc; tetrakis(triphenylphosphine) palladium(0) 1) THF, 60 deg C, 9 h, 2) 45 deg C, 6 h; Yield given. Multistep reaction;

methanol (67-56-1) + 2-bromo-3,3,3-trifluoropropene (1514-82-5) → (Z)-1-Methoxy-3,3,3-trifluoroprop-1-ene (26885-67-6)

Conditions	Yield
With potassium hydroxide for 1h;	96%

ethanol (64-17-5) + 2-bromo-3,3,3-trifluoropropene (1514-82-5) → (Z)-1-ethoxy-3,3,3-trifluoroprop-1-ene (126015-28-9)

Conditions	Yield
With potassium hydroxide for 1h;	96%
With potassium hydroxide for 1h;	95%
Stage #1: 2-bromo-3,3,3-trifluoropropene With potassium hydroxide In water Stage #2: ethanol In water	95%

d,l-2-ethylhexanal (123-05-7) + 2-bromo-3,3,3-trifluoropropene (1514-82-5) → 5-Ethyl-1,1,1-trifluoronon-2-yn-4-ol

Conditions	Yield
With lithium diisopropyl amide In tetrahydrofuran; cyclohexane 1.) -78 deg C, 10 min, 2.) -78 deg C, 1 h;	96%

2-bromo-3,3,3-trifluoropropene (1514-82-5) + N-(2,2-dimethylpropylidene)-p-toluenesulfonamide (135822-92-3) → 4-methyl-N-[4,4-dimethyl-2-(trifluoromethyl)pent-1-en-3-yl]benzenesulfonamide

Conditions	Yield
Stage #1: 2-bromo-3,3,3-trifluoropropene With sec.-butyllithium In diethyl ether; cyclohexane at -105℃; for 0.166667h; Stage #2: N-(2,2-dimethylpropylidene)-p-toluenesulfonamide In diethyl ether; cyclohexane at -105 - -50℃; for 2h;	96%
Stage #1: 2-bromo-3,3,3-trifluoropropene; N-(2,2-dimethylpropylidene)-p-toluenesulfonamide With sec.-butyllithium In diethyl ether; cyclohexane at -105℃; for 0.166667h; Inert atmosphere; Stage #2: With boron trifluoride diethyl etherate In diethyl ether; cyclohexane at -105 - -50℃; for 2h; Inert atmosphere; Stage #3: With water In diethyl ether; cyclohexane pH=7; aq. phosphate buffer;	96%

2-bromo-3,3,3-trifluoropropene (1514-82-5) + benzaldehyde p-toluenesulfonylhydrazone (1666-17-7) → 3-(trifluoromethyl)-5-phenylpyrazole (4027-54-7, 948293-66-1)

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 60℃; for 6h;	96%

2-bromo-3,3,3-trifluoropropene (1514-82-5) + 4-Ethynylaniline (14235-81-5) → 4-(3-(trifluoromethyl)but-3-en-1-yn-1-yl)aniline

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 50℃; Inert atmosphere; Schlenk technique;	96%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 50℃; Inert atmosphere; Schlenk technique;

2-bromo-3,3,3-trifluoropropene (1514-82-5) + benzaldehyde (100-52-7) → 1-phenyl-2-(trifluoromethyl)-2-propen-1-ol (14633-65-9)

Conditions	Yield
With copper(l) chloride; zinc In N,N-dimethyl-formamide 1.) 20 deg C, 4 h, 2.) 50 deg C, 8h;	95%
Stage #1: 2-bromo-3,3,3-trifluoropropene With sec.-butyllithium In diethyl ether; cyclohexane at -105℃; for 0.166667h; Stage #2: benzaldehyde In diethyl ether; cyclohexane at -105 - -50℃; for 2h;	73%
Stage #1: 2-bromo-3,3,3-trifluoropropene With sec.-butyllithium In diethyl ether; cyclohexane at -105℃; for 0.166667h; Inert atmosphere; Stage #2: benzaldehyde In diethyl ether; cyclohexane at -105 - -50℃; for 2h; Inert atmosphere; Stage #3: With water In diethyl ether; cyclohexane pH=7; aq. phosphate buffer;	73%

2-bromo-3,3,3-trifluoropropene (1514-82-5) + 4-chlorobenzaldehyde (104-88-1) → 1-(4-Chloro-phenyl)-2-trifluoromethyl-prop-2-en-1-ol (155014-61-2)

Conditions	Yield
With copper(l) chloride; zinc In N,N-dimethyl-formamide 1.) 20 deg C, 4 h, 2.) 50 deg C, 5h;	95%
With zinc In tetrahydrofuran; pyridine at 50℃; Schlenk technique; Inert atmosphere;

2-bromo-3,3,3-trifluoropropene (1514-82-5) + trimethylsilylacetylene (1066-54-2) → (3-trifluoromethyl-but-3-en-1-ynyl)trimethylsilane (152327-70-3)

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tributyl-amine at 60℃; for 4h;	95%

2-bromo-3,3,3-trifluoropropene (1514-82-5) + 1-((3S,10R,13S,17S)-10,13-dimethyl-3-((tetrahydro-2H-pyran-2-yl)oxy)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone (35961-41-2) → 2-[(3S,8S,9S,10R,13S,14S,17S)-10,13-Dimethyl-3-(tetrahydro-pyran-2-yloxy)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-5,5,5-trifluoro-pent-3-yn-2-ol

Conditions	Yield
With lithium diisopropyl amide In tetrahydrofuran; cyclohexane 1.) -78 deg C, 10 min, 2.) -78 deg C, 1 h;	95%

2-bromo-3,3,3-trifluoropropene (1514-82-5) + 3-methoxy-1-iodobenzene (766-85-8) → 1-methoxy-3-(3,3,3-trifluoroprop-1-yn-1-yl)benzene (111727-07-2)

Conditions	Yield
Stage #1: 2-bromo-3,3,3-trifluoropropene With dichloro(N,N,N’,N‘-tetramethylethylenediamine)zinc; lithium diisopropyl amide In tetrahydrofuran; hexane at -78 - 20℃; for 1h; Stage #2: 3-methoxy-1-iodobenzene With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran; hexane for 6h; Heating;	95%

2-bromo-3,3,3-trifluoropropene (1514-82-5) + N-cyclohexylidenebenzylamine N-oxide (22687-06-5) → N-benzyl-N-(1-cyclohexyl-4,4,4-trifluorobut-2-ynyl)hydroxylamine (1170994-16-7)

Conditions	Yield
Stage #1: 2-bromo-3,3,3-trifluoropropene With lithium diisopropyl amide In tetrahydrofuran at -78℃; Stage #2: N-cyclohexylidenebenzylamine N-oxide In tetrahydrofuran at -20℃; for 2h;	95%

2-bromo-3,3,3-trifluoropropene (1514-82-5) + 3-phenylsydnone (508191-77-3) → 1-phenyl-4-(trifluoromethyl)-1H-pyrazole

Conditions	Yield
With 1,10-Phenanthroline; copper(II) bis(trifluoromethanesulfonate); 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 35℃; for 4h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; regioselective reaction;	95%

2-bromo-3,3,3-trifluoropropene (1514-82-5) + tert-butyl (2R)-2-[chloro(hydroxyimino)methyl]pyrrolidine-1-carboxylate (1148049-26-6) → (R)-tert-butyl 2-(5-(trifluoromethyl)isoxazol-3-yl)-pyrrolidine-1-carboxylate

Conditions	Yield
With sodium hydrogencarbonate In ethyl acetate at 20℃; regioselective reaction;	95%

Upstream product

• 431-21-0 1,2-Dibromo-3,3,3-trifluoropropane 
• 383-68-6 3-acetoxy-2-bromo-1,1,1-trifluoropropane 
• 421-44-3 2-bromo-3-chloro-3,3-difluoro-propene 
• 7783-56-4 antimony(III) fluoride 
• 107-06-2 1,2-dichloro-ethane 
• 28124-18-7 2-bromo-3,3,3-trichloro-propene 
• 311-86-4 2-bromo-3,3,3-trifluoropropan-1-ol 
• 19451-92-4 (2-bromo-3,3,3-trifluoro-propyl)-bis-trifluoromethyl-amine 
• 677-35-0 2,3-dibromo-3,3-difluoro-propene 

Downstream Products

• 14856-83-8 2-phenyl-3-(trifluoromethyl)but-3-en-2-ol 
• 136476-25-0 2,4-dinitro-α-(trifluoromethyl)styrene 
• 384-64-5 3,3,3-trifluoro-2-phenylpropene 
• 136476-26-1 2-(3,3,3-trifluoroprop-1-en-2-yl)benzaldehyde 
• 106240-88-4 N-(2-bromo-3,3,3,-trifluoropropyl)-N-benzylamine 
• 110397-70-1 5-phenyl-2-(trifluoromethyl)pent-1-en-3-ol 
• 171668-24-9 (E)-6,6,6-Trifluoro-1-phenyl-1-hexen-4-yn-3-ol 
• 94792-93-5 6,6,6-Trifluoro-1-phenyl-4-hexyn-3-ol 
• 96302-93-1 1-(3,3,3-trifluoro-1-propynyl)-1-cyclohexanol 
• 149846-93-5 1-phenyl-4,4,4-trifluorobut-2-yn-1-ol 
• 14629-77-7 1-phenyl 1-hydroxy 1-methyl perfluoro butine-⁽²⁾ 
• 95540-90-2 1-Cyclohexyl-4,4,4-trifluoro-2-butyn-1-ol 
• 26885-67-6 (Z)-1-Methoxy-3,3,3-trifluoroprop-1-ene 
• 186143-62-4 1,1-Diphenyl-4,4,4-trifluorobut-2-yn-1-ol 

Relevant articles and documents

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The study of thermal decomposition of 2-bromo-3,3, 3-trifluoropropene and its fire-extinguishing mechanism

As a new kind of Halon replacement, 2-bromo-3,3,3-trifluoropropene (BTP) is highly effective at fire suppression with an extinguishment concentration lower than that of Halon 1301. Although the physical properties and extinguishing characteristics of BTP have been widely reported, there are relatively few studies on its thermal pyrolysis and extinguishing mechanisms. In this study, the thermal decomposition of BTP was studied over a temperature range of 25-800 8C and the decomposition products were analyzed by GC and GC-MS. Experimental results showed that the decomposition products were mainly trifluoropropyne (CF3CCH) and/or bromotrifluoromethane (CF3Br). The calculated apparent activation energies for the thermal pyrolysis of BTP by first order reaction approximation were in excellent agreement with the theoretical calculation results by Gaussian 03. Furthermore, by analyzing decomposition products and their chemical inhibition effect, thermal decomposition mechanism of BTP and its chemical extinguishing mechanism at high temperature were then proposed.

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PREPARATION OF 2,3,3,3-TETRAFLUOROPROPENE, INTERMEDIATE AND COMPOSITION THEREOF

The present invention provides a process for preparation of 2,3,3,3-tetrafluoropropene, intermediate and composition thereof. Fluoro olefins play an important role as refrigerants. In recent years a fluoro olefin viz. 2,3,3,3-tetrafluoropropene (HFO-1234yf) has attracted attention as a new refrigerant to replace another fluorinated refrigerants.

STABILIZED 2-BROMO-3,3,3-TRIFLUOROPROPENE COMPOSITION AND METHOD FOR PRODUCING THE SAME, AND METHOD FOR STABILIZING THE SAME

PROBLEM TO BE SOLVED: To provide a composition in which unstable 2-bromo-3,3,3-trifluoropropene is stabilized and a method therefor. SOLUTION: Water of 50 μg/g or more is added to 2-bromo-3,3,3-trifluoropropene, to stabilize 2-bromo-3,3,3-trifluoropropene. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT