1514-87-0

Basic information

• Product Name: METHYL CHLORODIFLUOROACETATE
• Synonyms: Acetic acid, chlorodifluoro-, methyl ester;chlorodifluoro-aceticacimethylester;CHLORODIFLUOROACETIC ACID METHYL ESTER;METHYL 2-CHLORO-2,2-DIFLUOROACETATE;METHYL DIFLUOROCHLOROACETIC ACID;METHYL CHLORODIFLUOROACETATE;Methyl chlorodifluoroacetate 99%;Methylchlorodifluoroacetate99%
• CAS NO: 1514-87-0
• Molecular Formula: C₃H₃ClF₂O₂
• Molecular Weight: 144.5
• EINECS: 216-154-9
• Product Categories: Fluorinated Building Blocks;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;Synthetic Organic Chemistry;C2 to C5;Carbonyl Compounds;Esters
• Mol File: 1514-87-0.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 79-81 °C(lit.)
• Flash Point: 67 °F
• Appearance: Clear colorless/Liquid
• Density: 1.37 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.349(lit.)
• Storage Temp.: Flammables area
• Sensitive: Moisture Sensitive
• BRN: 1756072
• CAS DataBase Reference: METHYL CHLORODIFLUOROACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL CHLORODIFLUOROACETATE(1514-87-0)
• EPA Substance Registry System: METHYL CHLORODIFLUOROACETATE(1514-87-0)

Safety Data

• Hazard Codes: F,C
• Statements: 11-34-37
• Safety Statements: 16-26-36/37/39-45
• RIDADR: UN 2924 3/PG 2
• WGK Germany: 3
• F: 19
• TSCA: Yes
• HazardClass: 3
• PackingGroup: II
• Hazardous Substances Data: 1514-87-0(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

Methyl chlorodifluoroacetate was used in preparation of 2,2-difluoro-3-hydroxyesters and gem-difluorocyclopropane.

General Description

Methyl chlorodifluoroacetate is a trifluoromethylating agent.

InChI:InChI=1S/C3H3ClF2O2/c1-8-2(7)3(4,5)6/h1H3

Upstream product

• 354-24-5 chlordifluoroacetyl chloride 
• 404582-64-5 2-chloro-1,1,2,2-tetrafluoro-2-methoxyethane 
• 67-56-1 methanol 
• 754-28-9 1,2-dichloro-1,1,2-trifluoro-2-methoxyethane 
• 1895-39-2 sodium chlorodifluoroacetate 
• 598-99-2 Methyl trichloroacetate 
• 354-27-8 chlorodifluoroacetyl fluoride 
• 76-04-0 2-chloro-2,2-difluoroacetic acid 

Downstream Products

• 2375-76-0 1-chloro-1,1-difluoropentane-2,4-dione 
• 98-08-8 α,α,α-trifluorotoluene 
• 74-88-4 methyl iodide 
• 353-83-3 1,1,1-trifluoro-2-iodoethane 
• 401-79-6 1-methyl-3-trifluoromethyl-benzene 
• 6140-17-6 4-methylbenzotrifluoride 
• 74031-42-8 (3,3,3-trifluoroprop-1-enyl)benzene 
• 384-22-5 2-nitrobenzotrifluoride 
• 86340-72-9 1-chloro-1,1-difluoro-3-phenyl-2-propanone 
• 141708-85-2 1-chloro-1,1-difluoro-6-phenyl-2-pentanone 
• 384-67-8 2-chloro-2,2-difluoroacetophenone 
• 2314-97-8 iodotrifluoromethane 
• 124-38-9 carbon dioxide 
• 1184-76-5 difluorodiiodomethane 

Relevant articles and documents

Esterification of 1,2-dichloro-1,1,2-trifluoro-2-methoxyethane with AlFm(OH)3-m

Porous AlFm(OH)3-m was prepared by heating AlF3·3H2O. Methyl chlorodifluoroacetate was synthesized in 77% yield by the reaction of 1,2-dichloro-1,1,2-trifluoro-2-methoxyethane with AlFm(OH)3-m/s

Synthesis, characterisation and mass spectrometric fragmentation of O-(chlorodifluoroacylated) alcohols

An indirect and uncatalysed esterification of chlorodifluoroacetic acid with polyfluoro and hydrocarbon alcohols has been developed. The method which involves the reaction between sodium chlorodifluoroacetate and alcohols in dimethylformamide (DMF) is par

Defluorination of homologous chlorofluoroethers to chlorofluoroacetates

The research was focused on the defluorination of chlorofluoroethers to corresponding esters using porous aluminum fluoride (PAF) or MFn/PAF. In the work up process, the product was easily separated from the reagent. Thus, the reaction would be a practical preparation method for polyfluorinated esters. Trifluoromethyl chlorodifluoroacetate was obtained by the reaction of 1,2-dichlorotrifluoroethyltrifluoromethyl ether with fuming sulfuric acid in 49% yield.

Preparation of compounds comprising a CHF2 or CHF group

Producing compounds (I) with a mono- or difluoromethyl group from compounds (II) with a mono- or difluorohalomethyl group, where halo is bromo, iodo or preferably chloro, comprises reacting (II) with zinc in the presence of an alcohol. An independent claim is also included for an azeotropic mixture of methyl difluoroacetate and methanol.