151410-01-4

Basic information

• Product Name: 2-[1-(4-Methyl-benzyl)-1H-indol-3-yl]-ethylamine
• Synonyms: 2-[1-(4-Methyl-benzyl)-1H-indol-3-yl]-ethylamine
• CAS NO: 151410-01-4
• Molecular Weight: 264.37
• Mol File: 151410-01-4.mol

Chemical Properties

• CAS DataBase Reference: 2-[1-(4-Methyl-benzyl)-1H-indol-3-yl]-ethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[1-(4-Methyl-benzyl)-1H-indol-3-yl]-ethylamine(151410-01-4)
• EPA Substance Registry System: 2-[1-(4-Methyl-benzyl)-1H-indol-3-yl]-ethylamine(151410-01-4)

Safety Data

• Hazardous Substances Data: 151410-01-4(Hazardous Substances Data)

Upstream product

• 151409-79-9 1-[(4-methylphenyl)methyl]-1H-indole-3-carboxaldehyde 
• 104-82-5 4-Methylbenzyl chloride 
• 487-89-8 Indole-3-carboxaldehyde 

Downstream Products

• 1054644-81-3 (3aS,4S,6R,6aR)-2,2-Dimethyl-6-(6-{2-[1-(4-methyl-benzyl)-1H-indol-3-yl]-ethylamino}-purin-9-yl)-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid cyclopropylamide 

Relevant articles and documents

N6-Substituted Adenosine Receptor Agonists. Synthesis and Pharmacological Activity as Potent Antinociceptive Agents

Novel N6-(indol-3-yl)alkyl derivatives of adenosine were synthesized.The adenosine receptor affinity and the antinociceptive activity of these compounds were assessed in binding studies and the phenylbenzoquinone-induced writhing test.Most of these analogues exhibited a potent analgesic activity without side effects.Among them, compound 3c (UP 202-32) bound to A1 (Ki = 110 nM) and A2 (Ki = 350 nM) adenosine receptors in a specific manner since it did not interact with many other receptors, especially opioid binding sites.The antinociceptive activity in the phenylbenzoquinone assay (ED50 = 3.3 mg/kg po) was antagonized by 8-cyclopentyltheophylline, suggesting that an adenosinergic mechanism underlies the analgesic activity observed with this compound.The data obtained with these new N6-substituted adenosine receptor agonists emphasize the interest of such compounds in the treatment of pain.