151411-98-2 Usage
General Description
2,4,6-Trifluorobenzyl bromide is a chemical compound with the molecular formula C7H4BrF3. It is an aromatic organic compound that contains three fluorine atoms and a bromine atom attached to a benzene ring. 2,4,6-Trifluorobenzyl bromide is commonly used as a reagent in organic synthesis to introduce the trifluoromethyl group into various organic compounds. It is also used in the pharmaceutical industry to synthesize new drugs and in agrochemical research to develop new pesticides. Additionally, it is a useful building block for the preparation of various fluorinated organic compounds. 2,4,6-TRIFLUOROBENZYL BROMIDE is flammable and should be handled with care in a well-ventilated area.
Check Digit Verification of cas no
The CAS Registry Mumber 151411-98-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,1,4,1 and 1 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 151411-98:
(8*1)+(7*5)+(6*1)+(5*4)+(4*1)+(3*1)+(2*9)+(1*8)=102
102 % 10 = 2
So 151411-98-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H4BrF3/c8-3-5-6(10)1-4(9)2-7(5)11/h1-2H,3H2
151411-98-2Relevant articles and documents
Optimization of benzyloxazoles as non-nucleoside inhibitors of HIV-1 reverse transcriptase to enhance Y181C potency
Bollini, Mariela,Gallardo-Macias, Ricardo,Spasov, Krasimir A.,Tirado-Rives, Julian,Anderson, Karen S.,Jorgensen, William L.
, p. 1110 - 1113 (2013/03/14)
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved activity towards Tyr181Cys containing variants was pursued with the assistance of free energy perturbation (FEP) calculations. Optimization of the 4-R substituent in 1 led to ethyl and isopropyl analogs 1e and 1f with 1-7 nM potency towards both the wild-type virus and a Tyr181C variant.
