151411-98-2 Usage
Uses
Used in Organic Synthesis:
2,4,6-Trifluorobenzyl bromide is used as a reagent for introducing the trifluoromethyl group into organic compounds. Its application is crucial in enhancing the properties of these compounds, such as increasing their lipophilicity and metabolic stability, which are important factors in drug design and development.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,4,6-trifluorobenzyl bromide is utilized as an intermediate in the synthesis of new drugs. Its unique structure and properties contribute to the development of innovative therapeutic agents with improved efficacy and selectivity.
Used in Agrochemical Research:
2,4,6-Trifluorobenzyl bromide is also employed in agrochemical research for the development of new pesticides. The incorporation of the trifluoromethyl group can lead to the creation of more effective and environmentally friendly agrochemicals.
Used in the Preparation of Fluorinated Organic Compounds:
As a building block, 2,4,6-trifluorobenzyl bromide is instrumental in the preparation of various fluorinated organic compounds. These compounds are known for their unique chemical and physical properties, making them valuable in a range of applications, including materials science, pharmaceuticals, and agrochemicals.
Safety Considerations:
Due to its flammable nature, 2,4,6-trifluorobenzyl bromide should be handled with caution in a well-ventilated area to minimize the risk of fire or explosion. Proper safety measures, including the use of personal protective equipment, should be adhered to during its manipulation and storage.
Check Digit Verification of cas no
The CAS Registry Mumber 151411-98-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,1,4,1 and 1 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 151411-98:
(8*1)+(7*5)+(6*1)+(5*4)+(4*1)+(3*1)+(2*9)+(1*8)=102
102 % 10 = 2
So 151411-98-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H4BrF3/c8-3-5-6(10)1-4(9)2-7(5)11/h1-2H,3H2
151411-98-2Relevant academic research and scientific papers
Optimization of benzyloxazoles as non-nucleoside inhibitors of HIV-1 reverse transcriptase to enhance Y181C potency
Bollini, Mariela,Gallardo-Macias, Ricardo,Spasov, Krasimir A.,Tirado-Rives, Julian,Anderson, Karen S.,Jorgensen, William L.
, p. 1110 - 1113 (2013/03/14)
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved activity towards Tyr181Cys containing variants was pursued with the assistance of free energy perturbation (FEP) calculations. Optimization of the 4-R substituent in 1 led to ethyl and isopropyl analogs 1e and 1f with 1-7 nM potency towards both the wild-type virus and a Tyr181C variant.
