15144-80-6

Basic information

• Product Name: DIETHYL-(4-METHOXY-PHENYL)-AMINE
• Synonyms: DIETHYL-(4-METHOXY-PHENYL)-AMINE
• CAS NO: 15144-80-6
• Molecular Formula: C₁₁H₁₇NO
• Molecular Weight: 179.25878
• Mol File: 15144-80-6.mol
• Article Data: 31

Chemical Properties

• Appearance: /
• CAS DataBase Reference: DIETHYL-(4-METHOXY-PHENYL)-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: DIETHYL-(4-METHOXY-PHENYL)-AMINE(15144-80-6)
• EPA Substance Registry System: DIETHYL-(4-METHOXY-PHENYL)-AMINE(15144-80-6)

Safety Data

• Hazardous Substances Data: 15144-80-6(Hazardous Substances Data)

Upstream product

• 78-40-0 triethyl phosphate 
• 104-94-9 4-methoxy-aniline 
• 75-03-6 ethyl iodide 
• 557-20-0 diethylzinc 
• 75-05-8 acetonitrile 
• 100-17-4 para-methoxynitrobenzene 
• 696-62-8 para-iodoanisole 
• 109-89-7 diethylamine 
• 64-17-5 ethanol 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 5775-33-7 N-chlorodiethylamine 
• 82303-13-7 (4-methoxyphenyl)zinc(II) bromide 
• 783-08-4 [4-(benzylideneamino)phenyl]methanol 
• 1749-08-2 N-(4-methoxy benzylidene)-4-methoxyaniline 

Relevant articles and documents

PALLADIUM-CATALYZED AROMATIC AMINATION OF ARYL BROMIDES WITH N,N-DIETHYLAMINO-TRIBUTYLTIN

The reaction of N,N-diethylamino-tributyltin with aryl bromides in the presence of a catalytic amount of PdCl2(o-tolyl3P)2 gave N,N-diethylaminobenzene derivatives.The reaction is a new kind of amination different from ones through aryne or SRN1 mechanism.

Product selective reaction controlled by the combination of palladium nanoparticles, continuous microwave irradiation, and a co-existing solid; ligand-free Buchwald-Hartwig aminationvs.aryne amination

We have developed a continuous microwave irradiation-assisted Buchwald-Hartwig amination using our original Pd nanoparticle catalyst with a copper plate as a co-existing metal solid. In this methodology, a microwave-controlled product selectivity was achieved between Buchwald-Hartwig amination and aryne amination performed under strongly basic conditions and at a high reaction temperature, because a polar chemical species such as Ar-Pd-halogen might be activated selectively by microwave radiation. Moreover, our catalyst could be used repeatedly over 10 times, and the amount of Pd leaching could be suppressed to a low level.

Photocatalytic Water-Splitting Coupled with Alkanol Oxidation for Selective N-alkylation Reactions over Carbon Nitride

Photocatalytic water splitting technology (PWST) enables the direct use of water as appealing “liquid hydrogen source” for transfer hydrogenation reactions. Currently, the development of PWST-based transfer hydrogenations is still in an embryonic stage. Previous reports generally centered on the rational utilization of the in situ generated H-source (electrons) for hydrogenations, in which photogenerated holes were quenched by sacrificial reagents. Herein, the fully-utilization of the liquid H-source and holes during water splitting is presented for photo-reductive N-alkylation of nitro-aromatic compounds. In this integrate system, H-species in situ generated from water splitting were designed for nitroarenes reduction to produce amines, while alkanols were oxidized by holes for cascade alkylating of anilines as well as the generated secondary amines. More than 50 examples achieved with a broad range scope validate the universal applicability of this mild and sustainable coupling approach. The synthetic utility of this protocol was further demonstrated by the synthesis of existing pharmaceuticals via selective N-alkylation of amines. This strategy based on the sustainable water splitting technology highlights a significant and promising route for selective synthesis of valuable N-alkylated fine chemicals and pharmaceuticals from nitroarenes and amines with water and alkanols.

NEW METHOD FOR THE SYNTHESIS OF UNSYMMETRICAL TERTIARY AMINES

Disclosed is a new method for the synthesis of unsymmetrical tertiary amines using alcohol and an imine, and to new tertiary amines.