151447-04-0Relevant articles and documents
Mammalian topoisomerase II inhibitory activity of 1-cyclopropyl-6,8- difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl-4-oxo-3-quinolinecarboxylic acid and related derivatives
Wentland,Lesher,Reuman,Gruett,Singh,Aldous,Dorff,Rake,Coughlin
, p. 2801 - 2809 (1993)
1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4- oxo-3-quinolinecarboxylic acid (1), a previously reported potent inhibitor of bacterial DNA gyrase, was found to be interactive with mammalian topoisomerase II (topo II). In a DNA-clea