1514777-43-5

Basic information

• Product Name: 7-(4-(2-(3-(4-bromophenyl)furan-2(5H)-one-4-yloxy)ethyl)piperazin-1-yl)-1-(4-fluorophenyl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• CAS NO: 1514777-43-5
• Molecular Weight: 666.476
• Mol File: 1514777-43-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-(4-(2-(3-(4-bromophenyl)furan-2(5H)-one-4-yloxy)ethyl)piperazin-1-yl)-1-(4-fluorophenyl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(4-(2-(3-(4-bromophenyl)furan-2(5H)-one-4-yloxy)ethyl)piperazin-1-yl)-1-(4-fluorophenyl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(1514777-43-5)
• EPA Substance Registry System: 7-(4-(2-(3-(4-bromophenyl)furan-2(5H)-one-4-yloxy)ethyl)piperazin-1-yl)-1-(4-fluorophenyl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(1514777-43-5)

Safety Data

• Hazardous Substances Data: 1514777-43-5(Hazardous Substances Data)

Upstream product

• 100074-37-1 phenylacetic acid 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 1266239-20-6 C₁₂H₁₀Br₂O₃ 
• 98105-99-8 sarafloxacin 
• 100074-49-5 3-(4-bromophenyl)-4-hydroxyfuran-2(5H)-one 

Relevant articles and documents

Novel 3-arylfuran-2(5H)-one-fluoroquinolone hybrid: Design, synthesis and evaluation as antibacterial agent

3-Arylfuran-2(5H)-one, a novel antibacterial pharmacophore targeting tyrosyl-tRNA synthetase (TyrRS), was hybridized with the clinically used fluoroquinolones to give a series of novel multi-target antimicrobial agents. Thus, twenty seven 3-arylfuran-2(5H)-one-fluoroquinolone hybrids were synthesized and evaluated for their antimicrobial activities. Some of the hybrids exhibited merits from both parents, displaying a broad spectrum of activity against resistant strains including both Gram-negative and Gram-positive bacteria. The most potent compound (11) in antibacterial assay shows MIC50 of 0.11 μg/mL against Multiple drug resistant Escherichia coli, being about 51-fold more potent than ciprofloxacin. The enzyme assays reveal that 11 is a potent multi-target inhibitor with IC50 of 1.15 ± 0.07 μM against DNA gyrase and 0.12 ± 0.04 μM against TyrRS, respectively. Its excellent inhibitory activities against isolated enzymes and intact cells strongly suggest that 11 deserves to further research as a novel antibiotic.