1514823-98-3Relevant academic research and scientific papers
Chemoenzymatic total syntheses of ribisins A, B, and D, polyoxygenated benzofuran derivatives displaying NGF-potentiating properties
Lan, Ping,Banwell, Martin G.,Willis, Anthony C.
, p. 2829 - 2842 (2014/05/06)
Total syntheses of the structures, 1, 2, and 4, assigned to the biologically active natural products ribisins A, B, and D, respectively, have been achieved using the microbially derived and enantiomerically pure cis-1,2-dihydrocatechol 5 as starting material. Key steps include Suzuki-Miyaura cross-coupling, intramolecular Mitsunobu, and tandem epoxidation/rearrangement reactions. As a result of these studies, the structures of ribisins A and D have been confirmed while that of congener B was shown to be represented by 31 rather than 2.
Chemoenzymatic total synthesis and reassignment of the absolute configuration of ribisin C
Lan, Ping,Banwell, Martin G.,Ward, Jas S.,Willis, Anthony C.
supporting information, p. 228 - 231 (2014/01/23)
The enantiomerically pure and enzymatically derived cis-1,2-dihydrocatechol 5 has been converted, by two related pathways, into compounds 3 and ent-3. As a result, it has been determined that the true structure of the natural product ribisin C is represen
