151490-63-0Relevant academic research and scientific papers
(R)-2-Phenylglycine as a chiral auxiliary in the asymmetric synthesis of 2-azetidinones
Van Maanen,Jastrzebski,Verweij,Kieboom,Spek,Van Koten
, p. 1441 - 1444 (1993)
The chlorozinc enolate of ethyl-[(2,2,5,5-tetramethyl-1-aza-2,5-disila)cyclopentyl]acetate was reacted with the ZnCl2 complex of N-benzylidene-2-phenylglycine methyl ester in THF at -70°C. After removal of the protecting silyl moiety (3S, 4S, α
Asymmetric synthesis of β-lactams via the zinc-mediated glycine ester enolate - Imine condensation reaction using α-amino esters as the chiral auxiliary
Van Maanen,Kleijn,Jastrzebski,Verweij,Kieboom,Van Koten
, p. 4331 - 4338 (2007/10/02)
Imine esters of glycine, (R)-phenylglycine, (R)-(1,4-cyclohexadienyl)glycine and (S)-valine have been employed in the ester enolate-imine condensation via double activation with ZnCl2. The reaction of the chlorozinc enolate (1b) of ethyl (2,2,5
