151491-88-2

Upstream product

• 151521-94-7 dimethyl (R)-N-(triphenylmethyl)aspartate 
• 756-79-6 dimethyl methane phosphonate 
• 76-83-5 trityl chloride 
• 14358-33-9 dimethyl (R)-2-aminobutanedioate hydrochloride 

Downstream Products

• 129938-34-7 (R)-4-oxo-5-phosphononorvaline 

Relevant academic research and scientific papers

N-TRITYL PROTECTED ASPARTIC ACID DERIVATIVES FOR THE PREPARATION OF PHOSPHONATE NMDA ANTAGONISTS

The present invention related to novel (R)-dimethyl N-tritylaspartate and novel (R)-alkyl N-trityl-4-oxo-5-phosphononorvalinate derivatives which are useful in the preparation of the class of beta-ketophosphonate NMDA antagonists.

Synthesis of (R)-4-oxo-5-phosphononorvaline, an N-methyl-D-aspartic acid receptor selective β-keto phosphonate

(R)-4-Oxo-5-phosphononorvaline (1), a selective NMDA glutamate site antagonist, has been synthesized in four steps (overall yield = 31%) from (R)-aspartic acid, without racemization.