1514931-13-5

Basic information

• Product Name: 2-{[5-(4-methylphenyl)-1H-1,2,4-triazol-3-yl]sulfanyl}acetohydrazide
• Synonyms: 2-{[5-(4-methylphenyl)-1H-1,2,4-triazol-3-yl]sulfanyl}acetohydrazide
• CAS NO: 1514931-13-5
• Molecular Weight: 263.323
• Mol File: 1514931-13-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-{[5-(4-methylphenyl)-1H-1,2,4-triazol-3-yl]sulfanyl}acetohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{[5-(4-methylphenyl)-1H-1,2,4-triazol-3-yl]sulfanyl}acetohydrazide(1514931-13-5)
• EPA Substance Registry System: 2-{[5-(4-methylphenyl)-1H-1,2,4-triazol-3-yl]sulfanyl}acetohydrazide(1514931-13-5)

Safety Data

• Hazardous Substances Data: 1514931-13-5(Hazardous Substances Data)

Upstream product

• 874-60-2 4-methyl-benzoyl chloride 
• 64310-34-5 C₉H₉N₃S 
• 132895-43-3 2-(4-methylphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one 

Relevant articles and documents

Synthesis of N′-arylidene-2-(5-aryl-1H-1, 2, 4-triazol-3-ylthio) acetohydrazides as antidepressants

Abstract: A series of N′-arylidene-2-(5-aryl-1H-1, 2, 4-triazol-3-ylthio) acetohydrazide were synthesized. Condensation of aromatic aldehydes with 2-(5-aryl-1H-1, 2, 4-triazol-3-ylthio) acetohydrazide gave corresponding N′ -arylidene-2-(5-aryl-1H-1, 2, 4-triazol-3-ylthio) acetohydrazide. Spectral and elemental analysis was used for structural elucidation of novel 1, 2, 4-triazole schiff bases. The newly synthesized compounds were screened for their antidepressant activity by using tail suspension test in mice. Compound 4l showed significant activity among the series. Graphical Abstract: A series of new N′-arylidene-2-(5-aryl-1H-1, 2, 4-triazol-3-ylthio)acetohydrazide have been synthesized and characterized. The results revealed that compound 4l with bromo substitution exhibited promising antidepressant activity among the series. [InlineMediaObject not available: see fulltext.].