15150-24-0Relevant articles and documents
Organotin-catalyzed synthesis of hydroxyalkylamides from lactones via a ring-opening process
Liang, Xiayu,Yu, Peng,Fu, Chen,Shen, Yongcun
supporting information, (2021/02/09)
A new strategy for the facile synthesis of hydroxyalkylamides through the ring-opening reaction of lactone with amine promoted by dibutyltin acetate was developed. A series of hydroxyalkylamide compounds were obtained and the method was successfully applied to the synthesis of pharmaceutically active molecules tyrosinase inhibitor V and HDAC inhibitor VI via a three-step synthetic pathway. The broad substrate scope, mild reaction conditions and practical application proved the effectiveness, compatibility and practicality of this method.
Trimethylaluminium mediated amide bond formation in a continuous flow microreactor as key to the synthesis of rimonabant and efaproxiral
Gustafsson, Tomas,Ponten, Fritiof,Seeberger, Peter H.
, p. 1100 - 1102 (2008/09/21)
A safe, functional-group-tolerant and high-throughput version of the trimethylaluminium mediated amide bond formation reaction has been developed in a microreactor system; rimonabant and efaproxiral were prepared to illustrate the utility of the method. The Royal Society of Chemistry.