151503-27-4

Upstream product

• 28585-50-4 3’-O-acetyl-2’-deoxy-2-thiothymidine 
• 59211-01-7 3’-O-acetyl-2,5’-anhydrothymidine 
• 15425-09-9 3,5'-cyclo-2'-deoxyguanosine 
• 28585-51-5 2-thiothymidine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 125258-60-8 1-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one 
• 151503-25-2 3'-p-toluoyl-2-thiothymidine 

Downstream Products

• 144988-68-1 5’-O-(4,4’-dimethoxytrityl)-2’-deoxy-5-methyl-4-pyrimidinone 2-cyanoethyl N,N-diisopropylphosphoramidite 

Relevant academic research and scientific papers

Polymerase recognition of 2-thio-iso-guanine·5-methyl-4-pyrimidinone (iGs·P) - A new DD/AA base pair

Polymerase specificity is reported for a previously unknown base pair with a non-standard DD/AA hydrogen bonding pattern: 2-thio-iso-guanine·5-methyl-4-pyrimidinone. Our findings suggest that atomic substitution may provide a solution for low fidelity previously associated with enzymatic copying of iso-guanine.

Efficient desulfurization of 2-thiopyrimidine nucleosides to the corresponding 4-pyrimidinones

A procedure is described for the preparation of 2'-deoxy-4-pyrimidinone (dH2U) and 2'-deoxy-5-methyl-4-pyrimidinone (dH2T) nucleosides. The key transformation is a nearly quantitative desulfurization of the corresponding 2-thio analo

The synthesis of oligodeoxynucleotides containing 2-thiothymine and 5-methyl-4-pyrimidinone base analogues

A procedure is described for the preparation of two thymidine analogues in which the O2-carbonyl is deleted (dH2T) or converted to an O2-thione (ds2T). The phosphoramidites of these nucleosides have been synthes