151503-27-4Relevant articles and documents
Polymerase recognition of 2-thio-iso-guanine·5-methyl-4-pyrimidinone (iGs·P) - A new DD/AA base pair
Lee, Dong-Kye,Switzer, Christopher
, p. 1177 - 1179 (2016)
Polymerase specificity is reported for a previously unknown base pair with a non-standard DD/AA hydrogen bonding pattern: 2-thio-iso-guanine·5-methyl-4-pyrimidinone. Our findings suggest that atomic substitution may provide a solution for low fidelity previously associated with enzymatic copying of iso-guanine.
Efficient desulfurization of 2-thiopyrimidine nucleosides to the corresponding 4-pyrimidinones
Kuimelis,Nambiar
, p. 3813 - 3816 (2007/10/02)
A procedure is described for the preparation of 2'-deoxy-4-pyrimidinone (dH2U) and 2'-deoxy-5-methyl-4-pyrimidinone (dH2T) nucleosides. The key transformation is a nearly quantitative desulfurization of the corresponding 2-thio analo
The synthesis of oligodeoxynucleotides containing 2-thiothymine and 5-methyl-4-pyrimidinone base analogues
Rajur,McLaughlin
, p. 6081 - 6084 (2007/10/02)
A procedure is described for the preparation of two thymidine analogues in which the O2-carbonyl is deleted (dH2T) or converted to an O2-thione (ds2T). The phosphoramidites of these nucleosides have been synthes