15151-98-1Relevant academic research and scientific papers
Identification of dialkyl diacetylene diols with potent cancer chemopreventive activity
Lee, Chang-Yong,Yun, Ji Ho,Kang, Kyungsu,Nho, Chu-Won,Shin, Dongyun
, p. 4020 - 4023 (2015)
Abstract An increasing importance of chemoprevention for controlling cancer risks prompted the discovery of new active cancer chemopreventive agents. In this study, we designed and synthesized substituted hexa-2,4-diyne-1,6-diols, more structurally simplified, tunable, and easily preparable than natural gymnasterkoreaynes, and evaluated their cancer chemopreventive activities by measuring concentration of doubling quinone reductase activity (CD), cell viability, and chemopreventive index (CI). Most of the diols exhibited good CD activity and low cytotoxicity. In particular, tetradeca-5,7-diyne-4,9-diol and 2-methyltetradeca-5,7-diyne-4,9-diol showed the best cancer chemopreventive activity, approximately equipotent to that of sulforaphane. And, by synthesizing optically active stereoisomers of selected active compounds, the effect of stereochemistry was also studied. Eventually, we produced a chemopreventive compound for in vivo study.
NOVEL DYNEDIOL COMPOUNDS AND CANCER TREATING COMPOSITION CONTAINING THEREOF
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Paragraph 0259-0263, (2020/04/01)
The present invention relates to a novel dynediol compound derivative; and cancer treatment by compounds thereof.
