151555-47-4 Usage
Uses
RU 58668 is a pure antiestrogen.
Definition
ChEBI: A 17beta-hydroxy steroid that is 17beta-estradiol in the the hydrogen at the 11beta position has been replaced by a p-({5-[(4,4,5,5,5-pentafluoropentyl)sulfonyl]pentyl}oxy)phenyl group. RU 586
8 is a pure anti-estrogen that downregulates estrogen receptor expression (IC50 = 0.04 nM).
Biological Activity
Pure antiestrogen that downregulates estrogen receptor expression (IC 50 = 0.04 nM). Displays potent antiproliferative activity in vitro (IC 50 = 0.035 - 0.09 nM in MCF-7 cells) and causes long term regression of tamoxifen-resistant MCF-7 xenografts in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 151555-47-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,1,5,5 and 5 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 151555-47:
(8*1)+(7*5)+(6*1)+(5*5)+(4*5)+(3*5)+(2*4)+(1*7)=124
124 % 10 = 4
So 151555-47-4 is a valid CAS Registry Number.
InChI:InChI=1/C34H43F5O5S/c1-32-21-28(31-26-13-9-24(40)20-23(26)8-12-27(31)29(32)14-15-30(32)41)22-6-10-25(11-7-22)44-17-3-2-4-18-45(42,43)19-5-16-33(35,36)34(37,38)39/h6-7,9-11,13,20,27-31,40-41H,2-5,8,12,14-19,21H2,1H3/t27-,28?,29-,30-,31+,32-/m0/s1
151555-47-4Relevant articles and documents
POLYMORPHS OF 19-NOR STEROID DERIVATIVES
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Page/Page column 10, (2008/06/13)
Crystalline polymorphic Forms A or B of 11β-[4-[5-[(4,4,5,5,5-pentafluoropentyl)suI-fonyl]pentyloxy] phenyl]-estra-1,3,5(10)-triene-3,17β-diol, their preparation, use and the pharmaceutical compositions comprising Form B.
