151559-40-9Relevant academic research and scientific papers
Efficient asymmetric hydrogenation of β- and γ-amino ketone derivatives leading to practical synthesis of fluoxetine and eprozinol
Sakuraba,Achiwa
, p. 748 - 753 (2007/10/02)
N-(Methylcarbamoyl)-4-(dicyclohexylphosphino)-2-[(diphenylphosphino)me thyl]pyrrolidine (MCCPM)- and N-(tert-butoxycarbonyl)-4-(dicyclohexylphosphino)-2-[(diphenylphosphin o)methyl]pyrrolidine (BCPM)-rhodium(I) complexes were efficient catalysts for asymmetric hydrogenations of β- and γ-amino ketone hydrochloride derivatives. Utilizing this methodology, we have developed efficient syntheses of fluoxetine and eprozinol from intermediate optically active amino alcohols.
An efficient synthesis of optically active eprozinol
Sakuraba,Nakajima,Achiwa
, p. 1457 - 1460 (2007/10/02)
A synthetic route to optically active eprozinol has been developed by efficient asymmetric hydrogenations of α- and β-amino ketone hydrochloride derivatives with MCCPM-rhodium catalyst.
