151568-75-1Relevant academic research and scientific papers
Applications of crotyldiisopinocampheylboranes in synthesis: A formal total synthesis of (+)-calyculin A
Anderson, Oren P.,Barrett, Anthony G.M.,Edmunds, Jeremy J.,Hachiya, Shun-Ichiro,Hendrix, James A.,Horita, Kiyoshi,Malecha, James W.,Parkinson, Christopher J.,Vansickle, Andrew
, p. 1562 - 1592 (2001)
The formal total synthesis of the marine metabolite (+)-calyculin A is reported. The key steps involve (i) the use of Brown allylboration chemistry to control the relative and absolute stereochemistry of homoallylic alcohol arrays, thus setting eight of the desired stereocenters; (ii) Stille coupling methodology in the construction of the cyano tetraene unit of the natural product; and (iii) a modified Cornforth-Meyers approach to the synthesis of the oxazole fragment.
A New Synthesis of Vinyltins by Reaction of Phosphorus Ylides with Acyltins
Verlhac, Jean-Baptiste,Kwon, HeeAn,Pereyre, Michel
, p. 1367 - 1368 (2007/10/02)
Acyltins react with various phosphorus ylides to afford the corresponding vinyltin derivatives, an alternative methodology for the preparation of these useful reagents.This method has been applied to the synthesis of functionally substituted vinyltins.
