151587-55-2

Basic information

• Product Name: 2-[(DiMethylaMino)Methylene]aMino-3N-(pivaloyloxy)Methyl-6-Methyl-5-nitro-4-pyriMidinol
• Synonyms: 2-[(DiMethylaMino)Methylene]aMino-3N-(pivaloyloxy)Methyl-6-Methyl-5-nitro-4-pyriMidinol;2,2-DiMethyl-propanoic Acid [2-[[(DiMethylaMino)Methylene]aMino]-4-Methyl-5-nitro-6-oxo-1(6H)-pyriMidinyl]Methyl Ester
• CAS NO: 151587-55-2
• Molecular Formula: C14H21N5O5
• Molecular Weight: 339.34704
• Product Categories: Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 151587-55-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Solubility: Dichloromethane, Ethyl Acetate
• CAS DataBase Reference: 2-[(DiMethylaMino)Methylene]aMino-3N-(pivaloyloxy)Methyl-6-Methyl-5-nitro-4-pyriMidinol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(DiMethylaMino)Methylene]aMino-3N-(pivaloyloxy)Methyl-6-Methyl-5-nitro-4-pyriMidinol(151587-55-2)
• EPA Substance Registry System: 2-[(DiMethylaMino)Methylene]aMino-3N-(pivaloyloxy)Methyl-6-Methyl-5-nitro-4-pyriMidinol(151587-55-2)

Safety Data

• Hazardous Substances Data: 151587-55-2(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Upstream product

• 18997-19-8 Chloromethyl pivalate 
• 4214-85-1 2-amino-6-methyl-5-nitro-4(3H)-oxopyrimidine 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 3977-29-5 2-amino-6-methyl-3H-pyrimidin-4-one 
• 151587-54-1 2-<<(N,N-Dimethylamino)methylene>amino>-6-methyl-5-nitro-4(3H)-oxopyrimidine 

Downstream Products

• 151587-57-4 2,2-Dimethyl-propionic acid 2-(dimethylamino-methyleneamino)-4-((E)-2-dimethylamino-vinyl)-5-nitro-6-oxo-6H-pyrimidin-1-ylmethyl ester 
• 169134-88-7 Dimethyl N-<4-<2-<2-<<(N,N-dimethylamino)methylene>amino>-4(3H)-oxo-3-<(pivaloyloxy)methyl>-5H-pyrrolo<3,2-d>pyrimidin-5-yl>ethyl>benzoyl>-L-glutamate 
• 169134-92-3 Dimethyl N-<4-<3-<2-<<(N,N-dimethylamino)methylene>amino>-4(3H)-oxo-3-<(pivaloyloxy)methyl>-5H-pyrrolo<3,2-d>pyrimidin-5-yl>propyl>benzoyl>-L-glutamate 
• 169134-90-1 tert-Butyl 4-<3-<2-<<(N,N-dimethylamino)methylene>amino>-3-<(pivaloyloxy)methyl>-4(3H)-oxo-5H-pyrrolo<3,2-d>pyrimidin-5-yl>propyl>benzoate 
• 169134-86-5 tert-Butyl 4-<2-<2-<<(N,N-dimethylamino)methylene>amino>-4(3H)-oxo-3-<(pivaloyloxy)methyl>-5H-pyrrolo<3,2-d>pyrimidin-5-yl>ethyl>benzoate 
• 169134-91-2 4-<3-<2-<<(N,N-Dimethylamino)methylene>amino>-4(3H)-oxo-3-<(pivaloyloxy)methyl>-5H-pyrrolo<3,2-d>pyrimidin-5-yl>propyl>benzoic acid 
• 169134-87-6 4-<2-<2-<<(N,N-Dimethylamino)methylene>amino>-4(3H)-oxo-3-<(pivaloyloxy)methyl>-5H-pyrrolo<3,2-d>pyrimidin-5-yl>ethyl>benzoic acid 
• 65996-58-9 9-deazaguanine 
• 151587-58-5 2-<<(N,N-Dimethylamino)methylene>amino>-4(3H)-oxo-3-<(pivaloyloxy)methyl>-5H-pyrrolo<3,2-d>pyrimidine 

Relevant articles and documents

Process for preparing 2-pyrrolidinyl-1H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside metabolism

A process of preparing a compound of the formula (I) wherein B is chosen from OH, NH2, NHR, H or halogen; D is chosen from OH, NH2, NHR, H halogen or SCH3; R is an optionally substituted alkyl, aralkyl or aryl group; and Z is selected from OH, hydrogen, halogen, hydroxy, SQ or OQ, Q is an optionally substituted all, aralkyl or aryl group; or a tautomer thereof; or a pharmaceutically acceptable salt thereof; or an ester thereof; or a prodrug thereof, which comprises reacting a compound of the formula (II) ?with an anion produced by abstraction of the bromine or iodine atom from a compound of formula (XIX), ?to form a compound of formula (XX) The compound of formula (XX) is N- and O-deprotected to obtain the compound of formula (I).

An expeditious synthesis of 2-amino-4(3H)-oxo-5H-pyrrolo[3,2-d]pyrimidine (9-deazaguanine)

9-Deazaguanine has been synthesized in five steps from 2-amino-6-methyl-5-nitro-4(3H)-pyrimidinone by a modification of the Batcho-Leimgruber indole synthesis.