151597-78-3Relevant articles and documents
Synthesis and hypoxia-selective cytotoxicity of a 2-nitroimidazole mustard
Lee,Palmer,Wilson,Denny
, p. 1741 - 1744 (2007/10/03)
A four-step synthesis of 5-[N,N-bis(2-chloroethyl)amino]-1-methyl-2- nitroimidazole from 1-methyl2-nitroimidazole is described. This compound showed similar hypoxia-selective cytotoxicity to the dinitrobenzamide mustard SN 23862 in UV4 cells (ca. 40-fold), and superior selectivity (>7-fold) in repaircompetent AA8 cells.