1516-34-3Relevant academic research and scientific papers
Catalytic Asymmetric Synthesis of Quaternary Barbituric Acids
Del Pozo, Sandra,Vera, Silvia,Oiarbide, Mikel,Palomo, Claudio
supporting information, p. 15308 - 15311 (2017/11/06)
The catalytic asymmetric α-functionalization of prochiral barbituric acids, a subtype of pseudosymmetric 1,3-diamides, to yield the corresponding 5,5-disubstituted (quaternary) derivatives remains essentially unsolved. In this study 2-alkylthio-4,6-dioxopirimidines are designed as key 1,3-diamide surrogates that perform exceedingly in amine-squaramide catalyzed C-C bond forming reactions with vinyl ketones or Morita-Baylis-Hillmann-type allyl bromides as electrophiles. Mild acid hydrolysis of adducts affords barbituric acid derivatives with an in-ring quaternary carbon in unprecedented enantioselectivity, offering valuable materials for biological evaluations.
PURINONE DERIVATIVES AS HM74A AGONISTS
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Page/Page column 28, (2008/06/13)
The present invention relates to purinone derivatives which are agonists of the HM74a receptor. Further provided are compositions and methods of using the compounds herein, and their pharmaceutically acceptable salts for the treatment of disease.
