151607-33-9

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 134111-33-4 4'-thiothymidine 

Downstream Products

• 154821-09-7 1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-1,1-dioxo-tetrahydro-1λ⁶-thiophen-2-yl}-5-methyl-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

The chemical synthesis and X-ray structure of the sulfone of 4'-thiothymidine

Oxidation of 4'-thiothymidine with MCPBA results in its smooth conversion in high yield to the corresponding sulfone. The X-ray structure of this novel analogue showed that the sugar ring has a very similar conformation (C2'-endo, C3'-endo, S) to that fou

Amplification of 4′-thioDNA in the presence of 4′-thio-dTTP and 4′-thio-dCTP, and 4′-thioDNA-directed transcription in vitro and in mammalian cells

Herein we describe the synthesis of 4′-thio-dTTP (1) and 4′-thio-dCTP (2) and their susceptibility for PCR amplification. Double stranded 4′-thioDNAs were amplified sufficiently by KOD dash DNA polymerase under appropriate conditions. Through this PCR stu

Compounds and oligomeric compounds comprising novel nucleobases

The present invention relates to nucleoside compositions comprising novel nucleobases and oligomeric compounds comprising at least one such nucleoside. These oligomeric compounds typically have enhanced binding affinity properties compared to oligomeric compounds without the modification. The oligomeric compounds are useful, for example, for investigative and therapeutic purposes.