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CAS

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151636-78-1

(2'R,3'S)-7,10-di-Troc-docetaxel is a potent chemical compound derived from the natural product docetaxel and belongs to the taxane family. It is characterized by the presence of a Troc (4,4,5,5-tetramethyl-2-(1,3,2)dioxaborolane) group, which enhances its stability and ease of handling in laboratory settings. (2'R,3'S)-7,10-di-Troc-docetaxel has demonstrated significant anti-cancer properties, making it a promising candidate for cancer therapy.

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  • 151636-78-1 Structure

  • Basic information

    1. Product Name: (2'R,3'S)-7,10-di-Troc-docetaxel
    2. Synonyms: (2'R,3'S)-7,10-di-Troc-docetaxel
    3. CAS NO:151636-78-1
    4. Molecular Formula:
    5. Molecular Weight: 1158.69
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 151636-78-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (2'R,3'S)-7,10-di-Troc-docetaxel(CAS DataBase Reference)
    10. NIST Chemistry Reference: (2'R,3'S)-7,10-di-Troc-docetaxel(151636-78-1)
    11. EPA Substance Registry System: (2'R,3'S)-7,10-di-Troc-docetaxel(151636-78-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 151636-78-1(Hazardous Substances Data)

151636-78-1 Usage

Uses

Used in Pharmaceutical Industry:
(2'R,3'S)-7,10-di-Troc-docetaxel is used as an anti-cancer agent for the treatment of various types of cancer, such as breast, prostate, and lung cancer. It functions by inhibiting the growth and spread of cancer cells through the disruption of the microtubule network within the cells, thereby preventing cell division and ultimately leading to cell death.
Used in Cancer Research:
In preclinical studies, (2'R,3'S)-7,10-di-Troc-docetaxel has shown promising results, making it a valuable compound for further investigation in cancer research. Its potential use in cancer therapy is currently being explored, with the aim of developing new and effective treatments for various types of cancer.

Check Digit Verification of cas no

The CAS Registry Mumber 151636-78-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,1,6,3 and 6 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 151636-78:
(8*1)+(7*5)+(6*1)+(5*6)+(4*3)+(3*6)+(2*7)+(1*8)=131
131 % 10 = 1
So 151636-78-1 is a valid CAS Registry Number.

151636-78-1Relevant articles and documents

METHOD FOR PREPARING TAXANE DERIVATIVES

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, (2012/02/15)

Provided is a method for preparing a taxane derivative, comprising: carrying out condensation of a phenylisoserine derivatives having a protective group introduced thereto or a mixture of isomers thereof, as a side chain, with a baccatin III derivative or 10-deacetyl-baccatin III derivative to obtain a mixture of isomers; separating the isomers via chromatography; and carrying out a reversion of the stereochemical structure of a selectively separated isomer, which is suitable for producing a taxane derivative in a large scale with high yield.

METHOD FOR PREPARING TAXANE DERIVATIVES

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Page/Page column 15-16, (2010/11/05)

Provided is a method for preparing a taxane derivative, comprising: carrying out condensation of a phenylisoserine derivatives having a protective group introduced thereto or a mixture of isomers thereof, as a side chain, with a baccatin III derivative or 10-deacetyl-baccatin III derivative to obtain a mixture of isomers; separating the isomers via chromatography; and carrying out a selective reversion of the stereochemical structure of a separated isomer, which is suitable for producing a taxane derivative in a large scale with high yield.

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