151670-69-8

Basic information

• Product Name: 2,6-Bis[(4S)-benzyl-2-oxazolin-2-yl]pyridine
• Synonyms: 2,6-Bis[(4S)-benzyl-2-oxazolin-2-yl]pyridine,99%e.e.;2,6-Bis[(4S)-benzyl-2-oxazolin-2-yl]pyridine, min. 98%;2,6-bis((S)-4-benzyl-4,5-dihydrooxazol-2-yl)pyridine
• CAS NO: 151670-69-8
• Molecular Formula: C₂₅H₂₃N₃O₂
• Molecular Weight: 397.46902
• Mol File: 151670-69-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 604.1±40.0 °C(Predicted)
• Appearance: white to light-yellow/Powder
• Density: 1.24±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.85±0.70(Predicted)
• CAS DataBase Reference: 2,6-Bis[(4S)-benzyl-2-oxazolin-2-yl]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Bis[(4S)-benzyl-2-oxazolin-2-yl]pyridine(151670-69-8)
• EPA Substance Registry System: 2,6-Bis[(4S)-benzyl-2-oxazolin-2-yl]pyridine(151670-69-8)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 151670-69-8(Hazardous Substances Data)

Usage

Reaction

Ligand for the Calcium-catalyzed asymmetric Mannich reaction of malonates with imines Ligand for the Scandium-catalyzed asymmetric dearomatization of 2-naphthols by electrophilic amination

Upstream product

• 3739-94-4 2,6-Pyridinedicarbonyl dichloride 
• 3182-95-4 L-Phenylalaninol 
• 133522-38-0 (S)-2-Amino-1-benzylethanol 
• 626-05-1 2,6-Dibromopyridine 
• 75866-71-6 (4S)-4-benzyl-4,5-dihydro-1,3-oxazole 
• 475110-11-3 N,N'-bis-[(1S)-1-(hydroxymethyl)-2-phenylethyl]-2,6-pyridinedicarboxamide 
• 695228-49-0 N²,N⁶-bis[(S)-1-chloro-3-phenylpropan-2-yl]pyridine-2,6-dicarboxamide 
• 499-83-2 Pyridine-2,6-dicarboxylic acid 
• 2893-33-6 pyridine-2,6-dinitrile 
• 55309-58-5 pyridine-2,6-dicarboximidic acid dimethyl ester 

Relevant articles and documents

Highly Chemo-, Regio-, and Stereoselective Cobalt-Catalyzed Markovnikov Hydrosilylation of Alkynes

A highly chemo-, regio- and stereoselective cobalt-catalyzed Markovnikov hydrosilylation of alkynes was developed. Various functionalized groups, such as halides, free alcohols, free aniline, ketones, esters, amides, and nitriles are tolerated, which may lead to further applications and late-stage derivatizations. To date, this is the most efficient cobalt catalytic system (TOF=65 520 h?1; TOF=turnover frequency) for hydrosilylation of alkynes. The Hiyama–Denmark cross-coupling reactions of vinylsilanes with aryl iodides underwent smoothly to afford 1,1-diarylethenes. A unique regioselectivity-controllable hydrosilylation/hydroboration reaction of alkynes was also described.

A Ce(OTf)3/PyBox catalyzed enantioselective Hosomi-Sakurai reaction of aldehydes with allyltrimethylsilane

An efficient enantioselective Hosomi-Sakurai reaction catalyzed by a chiral Ce(OTf)3/PyBox complex has been explored. In the presence of 20 mol% of a chiral catalytic complex prepared in situ from Ce(OTf)3 and 2,6-bis[(S)-4-isopropyl

Kinetic resolution by copper-catalyzed azide-alkyne cycloaddition

The use of chiral pybox ligands imparts enantioselectivity to the Cu I-catalyzed azide-alkyne cycloaddition reaction, in the form of kinetic resolution of α-chiral azides and desymmetrization of gem-diazides. While levels of selectivity are modest, the results show unequivocally that the process benefits from ligand-accelerated catalysis.