1516858-48-2

Basic information

• Product Name: 3-(4-fluoro-3-nitrophenyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide
• Synonyms: 3-(4-fluoro-3-nitrophenyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide
• CAS NO: 1516858-48-2
• Molecular Weight: 323.305
• Mol File: 1516858-48-2.mol

Chemical Properties

• CAS DataBase Reference: 3-(4-fluoro-3-nitrophenyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-fluoro-3-nitrophenyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide(1516858-48-2)
• EPA Substance Registry System: 3-(4-fluoro-3-nitrophenyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide(1516858-48-2)

Safety Data

• Hazardous Substances Data: 1516858-48-2(Hazardous Substances Data)

Upstream product

• 42564-51-2 4-fluoro-3-nitrobenzaldehyde 
• 3306-62-5 2-AMINOBENZENESULFONAMIDE 

Relevant articles and documents

Green approach toward one pot cascade synthesis of 3-aryl-3,4-dihydro-1,2,4 benzothiadiazine-1,1-dioxides

A silica-gel-supported ceric ammonium nitrate (CAN-SiO2) was found to be an effective catalyst for the cascade synthesis of functionalized 3-aryl-3,4-dihydro-1,2,4-benzo- thiadiazine-1,1-dioxides using 2-aminobenzenesulfonamide and benzaldehydes at room temperature. The reaction allows rapid cyclization (10-70 min) with 5 mol% CAN impregnated on silica gel to give the desired products in excellent yield without further column purification. The protocol uses inexpensive and environmentally friendly CAN-SiO2as the catalyst, and no ligand or additive was required. [Supplementary materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements for the following free supplemental files: Additional figures]