151698-54-3Relevant academic research and scientific papers
Synthesis of 3-substituted isocoumarins and their inhibitory effects on degranulation of RBL-2H3 cells induced by antigen
Kurume, Ai,Kamata, Yasuhiro,Yamashita, Masayuki,Wang, Qilong,Matsuda, Hisashi,Yoshikawa, Masayuki,Kawasaki, Ikuo,Ohta, Shunsaku
experimental part, p. 1264 - 1269 (2009/09/25)
Eleven 3-substituted isocoumarins and a benzylidenephthalide were synthesized through thermal cyclization reaction of δ- and γ-ketoamides, respectively. Subsequent deprotection of the hydroxyl groups of the resulting isocoumarin and benzylidenephthalide compounds afforded thunberginols A, B, and F., respectively, which originated from the processed leaves of Hydrangea macrophylla Seringe var. thunbergii MAKINO. The synthesized isocoumarins and thunberginols were evaluated for their anti-allergic activity, in which thunberginol B exhibited the highest inhibitory potency on the degranulation of RBL-2H3 cells induced by antigen. Structure - activity relationship studies were carried out to determine the necessary substituents on the 3-phenylisocoumarin skeleton for inhibitory activity.
A facile three-step synthesis of (dl)-6,8-dedihydroxyagrimonolide
Rama, Nasin H.,Iqbal, Rashid,Zamani, Khosrow,Saeed, Aamer,Choudhary, Iqbal Muhammad
, p. 480 - 483 (2007/10/03)
3-isocoumarin 2 has been prepared by the condensation of 4-methoxyphenylpropanoyl chloride with homophthalic acid.Alkaline hydrolysis of 2 yields the keto-acid 3 which is reconverted back to 2 either by treatment with acetic anh
Synthesis of 3-substituted isocoumarins and related natural products
Ohta,Kamata,Inagaki,Masuda,Yamamoto,Yamashita,Kawasaki
, p. 1188 - 1190 (2007/10/02)
Several N,N-diethyl-2-acylmethylbenzamides (6) were prepared from N,N- diethyl-2-toluamides (4), and the ketoamides (6) were easily cyclized to the corresponding 3-substituted isocoumarins (8) by heating in acetic acid or xylene. This simple procedure was
