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151707-53-8

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151707-53-8 Usage

General Description

The chemical compound "(2R,3R,4R,5R)-2-(4-amino-6-bromo-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((benzoyloxy)methyl)tetrahydrofuran-3,4-diyl dibenzoate" is a complex molecule consisting of a pyrrolopyrimidine ring fused with a tetrahydrofuran ring. It also contains benzoyloxy groups attached to the tetrahydrofuran ring. Additionally, it has a bromine atom and a cyano group attached to the pyrrolopyrimidine ring. (2R,3R,4R,5R)-2-(4-amino-6-bromo-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((benzoyloxy)methyl)tetrahydrofuran-3,4-diyl dibenzoate has potential pharmaceutical applications due to its structural features and may exhibit biological activity that could be useful in drug development.

Check Digit Verification of cas no

The CAS Registry Mumber 151707-53-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,1,7,0 and 7 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 151707-53:
(8*1)+(7*5)+(6*1)+(5*7)+(4*0)+(3*7)+(2*5)+(1*3)=118
118 % 10 = 8
So 151707-53-8 is a valid CAS Registry Number.

151707-53-8Relevant articles and documents

New small molecule inhibitors of histone methyl transferase DOT1L with a nitrile as a non-traditional replacement for heavy halogen atoms

Spurr, Sophie S.,Bayle, Elliott D.,Yu, Wenyu,Li, Fengling,Tempel, Wolfram,Vedadi, Masoud,Schapira, Matthieu,Fish, Paul V.

, p. 4518 - 4522 (2016/08/24)

A number of new nucleoside derivatives are disclosed as inhibitors of DOT1L activity. SARs established that DOT1L inhibition could be achieved through incorporation of polar groups and small heterocycles at the 5-position (5, 6, 12) or by the application of alternative nitrogenous bases (18). Based on these results, CN-SAH (19) was identified as a potent and selective inhibitor of DOT1L activity where the polar 5-nitrile group was shown by crystallography to bind in the hydrophobic pocket of DOT1L. In addition, we show that a polar nitrile group can be used as a non-traditional replacement for heavy halogen atoms.

Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors

Zhou, Longhu,Amblard, Franck,Zhang, Hongwang,McBrayer, Tamara R.,Detorio, Mervi A.,Whitaker, Tony,Coats, Steven J.,Schinazi, Raymond F.

, p. 3385 - 3388 (2013/06/27)

The synthesis of new ribo and 2′-β-C-methyl ribo Janus type nucleosides J-AA, J-AG and J-AU is reported along with their ability to block HCV and HIV replication. Their toxicity was also assessed in Huh7, human lymphocytes, CEM and Vero cells.

Total synthesis of the naturally occurring antibiotic toyocamycin using new and improved synthetic procedures

Porcari, Anthony R.,Townsend, Leroy B.

, p. 153 - 159 (2007/10/03)

Starting with commercially available tetracyanoethylene, we describe a more efficient and higher yielding synthesis of toyocamycin with regards to convenience, overall yield, and total reaction time than those syntheses previously reported.

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