15177-62-5

Basic information

• Product Name: trans-2-methylcyclohexanecarboxylic acid
• Synonyms: trans-2-methylcyclohexanecarboxylic acid;Ai3-33905;Cyclohexanecarboxylic acid, 2-methyl-, trans-;Einecs 239-227-7
• CAS NO: 15177-62-5
• Molecular Formula: C₈H₁₄O₂
• Molecular Weight: 142.19556
• EINECS: 239-227-7
• Mol File: 15177-62-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 170-172 °C
• Boiling Point: 242.2°Cat760mmHg
• Flash Point: 110.7°C
• Appearance: /
• Density: 1.025g/cm³
• Refractive Index: 1.467
• PKA: 5.43±0.28(Predicted)
• CAS DataBase Reference: trans-2-methylcyclohexanecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: trans-2-methylcyclohexanecarboxylic acid(15177-62-5)
• EPA Substance Registry System: trans-2-methylcyclohexanecarboxylic acid(15177-62-5)

Safety Data

• Hazardous Substances Data: 15177-62-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H14O2/c1-6-4-2-3-5-7(6)8(9)10/h6-7H,2-5H2,1H3,(H,9,10)/t6-,7-/m0/s1

Upstream product

• 87-41-2 2-benzofuran-1(3H)-one 
• 931-09-9 1-chloro-2-methyl-cyclohexane 
• 124-38-9 carbon dioxide 
• 10479-61-5 (+/-)-trans-2-Methyl-cyclohexancarbonitril 
• 821-41-0 5-Hexen-1-ol 
• 591-49-1 1-methylcyclohex-1-ene 
• 5406-30-4 (1RS,6RS)-6-methyl-3-cyclohexene-1-carboxylic acid 
• 5222-54-8 1,1-Dicyan-2-methyl-cyclohexan 
• 7076-91-7 (+-)-cis-2-methyl-cyclohexanecarboxylic acid 
• 5406-30-4 6-methyl-cyclohex-3-enecarboxylic acid 
• 120-18-3 naphthalene-2-sulfonate 
• 118-90-1 ortho-methylbenzoic acid 
• 201230-82-2 carbon monoxide 
• 82166-21-0 methyl cyclohexane 

Downstream Products

• 7132-88-9 (+/-)-trans-2-methyl-cyclohexanecarboxylic acid amide 
• 10479-71-7 trans-2-methyl-1-(ethoxycarbonyl)cyclohexane 
• 3937-46-0 (+/-)-(trans-2-Methyl-cyclohexyl)-methanol 
• 7605-54-1 trans-1-carbomethoxy-2-methylcyclohexane 

Relevant articles and documents

Exploration of New Biomass-Derived Solvents: Application to Carboxylation Reactions

A range of hitherto unexplored biomass-derived chemicals have been evaluated as new sustainable solvents for a large variety of CO2-based carboxylation reactions. Known biomass-derived solvents (biosolvents) are also included in the study and the results are compared with commonly used solvents for the reactions. Biosolvents can be efficiently applied in a variety of carboxylation reactions, such as Cu-catalyzed carboxylation of organoboranes and organoboronates, metal-catalyzed hydrocarboxylation, borocarboxylation, and other related reactions. For many of these reactions, the use of biosolvents provides comparable or better yields than the commonly used solvents. The best biosolvents identified are the so far unexplored candidates isosorbide dimethyl ether, acetaldehyde diethyl acetal, rose oxide, and eucalyptol, alongside the known biosolvent 2-methyltetrahydrofuran. This strategy was used for the synthesis of the commercial drugs Fenoprofen and Flurbiprofen.

Epimerization of 2- or 4- substituted cyclohexanecarboxylic acids

The present invention relates to a new method for obtaining a purity of about 93% to 100% of the trans form of 2- or 4-substituted cyclohexanecarboxylic acid or reactive derivatives thereof from the cis form or a mixture of the cis and trans forms by a single step, particularly, to a method for obtaining a purity of substantially 100% of the trans form of 4-substituted cyclohexanecarboxylic acid.

A CONVENIENT STEREOSPECIFIC ALKYLATION OF PHENYLACETYLENE BY ELECTROCHEMICAL REACTION OF ORGANOBORANES

The electrochemical reaction of phenylacetylene with trialkylboranes in a tetrahydrofuran solution containing tetraalkylammonium halide gives the corresponding alkynes via a retention of configuration with respect to the boron-carbon bonds.The reaction mechanism is also discussed.