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Relevant academic research and scientific papers

A General Approach for Generating Fluorescent Probes to Visualize Piconewton Forces at the Cell Surface

Mechanical forces between cells and their extracellular matrix (ECM) are mediated by dozens of different receptors. These biophysical interactions play fundamental roles in processes ranging from cellular development to tumor progression. However, mapping the spatial and temporal dynamics of tension among various receptor-ligand pairs remains a significant challenge. To address this issue, we have developed a synthetic strategy to generate modular tension probes combining the native chemical ligation (NCL) reaction with solid phase peptide synthesis (SPPS). In principle, this approach accommodates virtually any peptide or expressed protein amenable to NCL. We generated a small library of tension probes displaying different ligands, flexible linkers, and fluorescent reporters, enabling the mapping of integrin and cadherin tension, and demonstrating the first example of long-term (～3 days) molecular tension imaging. This approach provides a toolset to better understand mechanotransduction events fundamental to cell biology.

Superhydrophilicity and spontaneous spreading on zwitterionic surfaces: Carboxybetaine and sulfobetaine

Zwitterionic surfaces are fabricated by grafting sulfobetaine silane (SBSi) and carboxybetaine silane (CBSi) on glass slides. Their wetting behaviors are investigated using water, polar organic liquids, and hexadecane as test liquids. For the CBSi surface, partial wetting is observed, and contact angles of water and hexadecane are lower than 10°, revealing super-amphiphilicity. For the SBSi surface, all test liquids spread spontaneously and contact angles are absent, corresponding to total wetting. The time evolution of the wetting area of a liquid drop can be divided into three types: spread-withdrawal for water, spread-pin for polar organic liquids, and continuous spread for hexadecane. The spontaneous spreading on SBSi surfaces is driven by the high solid-gas interfacial tension and can be characterized by the power law. Although zwitterionic surfaces like both water and hexadecane in ambient air, their preference for water over hexadecane is typically demonstrated by a hexadecane drop in a water environment. Nonetheless, the contact angle of the hexadecane drop is 120°on the CBSi surface, but becomes 180°on the SBSi surface. As the zwitterionic surfaces are immersed in all test liquids, bubbles generally adhere to the CBSi surface but freely move beneath the SBSi surface. Our experimental results clearly show the wettability difference between the CBSi and SBSi surfaces. The former is superhydrophilic, while the latter is total wetting.

ZWITTERIONIC SILATRANE-BASED MATERIAL AND ANTIFOULING SUBSTRATE CONTAINING SAME

The present invention provides a zwitterionic silatrane-based material and an antifouling substrate containing the same, wherein zwitterionic silatrane-based material has a structure as shown in Formula (I):

MANUFACTURING METHOD OF BETAINE-BASED SILICON COMPOUND

To provide a method capable of easily manufacturing a betaine-based silicon compound which is a component of a coating composition forming a coated film hardly being detached from a substrate even in the case of contact with water, and having excellent anti-fogging properties and hydrophilicity on a surface of the substrate.SOLUTION: There is provided a manufacturing method of a betaine-based silicon compound represented by the following formula, by a direct reaction of a silicon compound having a dimethylamino group at a terminal and cyclic ester in no solvent. (X)(CH)Si-R-(X-R)-N(R)(R)-(CH)-Z, where Xrepresents an alkoxy group, a hydroxyl group or a halogen atom, k and m represent 0 or 1, Rrepresents an alkylene group, X represents -NHCOO-, -NHCONH-, -S-, or -SO-, Rrepresents an alkylene group which may contain an ether bond, an ester bond or an amide bond, or the like, Rand Rrepresent an alkyl group, n represents an integer of 3 to 10, and Z represents SOor CO.SELECTED DRAWING: None

SULFOBETAINE-BASED SILICON-BASED COMPOUND AND MANUFACTURING METHOD THEREFOR

PROBLEM TO BE SOLVED: To provide a method for easily manufacturing a sulfobetaine-based silicon-based compound which is a component of a coating composition which forms a coating hardly detaching from inorganic, carbon, metal and polymer substrates even when getting in contact with water, and having excellent antifogging and hydrophilic properties even on the surfaces of the substrates. SOLUTION: There is provided a manufacturing method of a compound represented by the following formula, by reacting a dialkyl amino group-containing silicon compound and cyclic sulfonic acid ester having 3 to 10 carbon atoms in a water soluble secondary or tertiary alcoholic solvent, a water soluble ether-based solvent having no primary alcoholic hydroxyl group, a water soluble ester-based solvent, a water soluble ketone-based solvent and an aprotic solvent. (R1O)3-k(R2)kSi-R3-(X-R4)m-N+(R5)(R6)-(CH2)n-SO3-, where R1, R2, R5 and R6 represent an alkyl group, R3 and R4 represent an alkylene group, X represents -NHCOO-, -NHCONH-, -S- or -SO2-. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT