151778-80-2Relevant articles and documents
A General Approach for Generating Fluorescent Probes to Visualize Piconewton Forces at the Cell Surface
Chang, Yuan,Liu, Zheng,Zhang, Yun,Galior, Kornelia,Yang, Jeffery,Salaita, Khalid
, p. 2901 - 2904 (2016)
Mechanical forces between cells and their extracellular matrix (ECM) are mediated by dozens of different receptors. These biophysical interactions play fundamental roles in processes ranging from cellular development to tumor progression. However, mapping the spatial and temporal dynamics of tension among various receptor-ligand pairs remains a significant challenge. To address this issue, we have developed a synthetic strategy to generate modular tension probes combining the native chemical ligation (NCL) reaction with solid phase peptide synthesis (SPPS). In principle, this approach accommodates virtually any peptide or expressed protein amenable to NCL. We generated a small library of tension probes displaying different ligands, flexible linkers, and fluorescent reporters, enabling the mapping of integrin and cadherin tension, and demonstrating the first example of long-term (~3 days) molecular tension imaging. This approach provides a toolset to better understand mechanotransduction events fundamental to cell biology.
ZWITTERIONIC SILATRANE-BASED MATERIAL AND ANTIFOULING SUBSTRATE CONTAINING SAME
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Paragraph 0040, (2020/01/24)
The present invention provides a zwitterionic silatrane-based material and an antifouling substrate containing the same, wherein zwitterionic silatrane-based material has a structure as shown in Formula (I):
SULFOBETAINE-BASED SILICON-BASED COMPOUND AND MANUFACTURING METHOD THEREFOR
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Paragraph 0058; 0059; 0060; 0061; 0070; 0071, (2018/05/17)
PROBLEM TO BE SOLVED: To provide a method for easily manufacturing a sulfobetaine-based silicon-based compound which is a component of a coating composition which forms a coating hardly detaching from inorganic, carbon, metal and polymer substrates even when getting in contact with water, and having excellent antifogging and hydrophilic properties even on the surfaces of the substrates. SOLUTION: There is provided a manufacturing method of a compound represented by the following formula, by reacting a dialkyl amino group-containing silicon compound and cyclic sulfonic acid ester having 3 to 10 carbon atoms in a water soluble secondary or tertiary alcoholic solvent, a water soluble ether-based solvent having no primary alcoholic hydroxyl group, a water soluble ester-based solvent, a water soluble ketone-based solvent and an aprotic solvent. (R1O)3-k(R2)kSi-R3-(X-R4)m-N+(R5)(R6)-(CH2)n-SO3-, where R1, R2, R5 and R6 represent an alkyl group, R3 and R4 represent an alkylene group, X represents -NHCOO-, -NHCONH-, -S- or -SO2-. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT