151898-58-7

Upstream product

• 64-17-5 ethanol 
• 151898-60-1 [[[2,6-Bis(1-methylethyl)phenyl]amino]sulfonyl]acetyl chloride 
• 55896-93-0 ethyl 2-(chlorosulfonyl)acetate 
• 24544-04-5 2,6-diisopropylbenzenamine 
• 123-43-3 sulfoacetic acid 
• 151898-59-8 (2,6-diisopropylphenylsulfamoyl)acetic acid 

Downstream Products

• 151898-60-1 [[[2,6-Bis(1-methylethyl)phenyl]amino]sulfonyl]acetyl chloride 
• 151898-59-8 (2,6-diisopropylphenylsulfamoyl)acetic acid 

Relevant academic research and scientific papers

Inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents: Synthesis and structure-activity relationships of novel series of sulfonamides, acylphosphonamides and acylphosphoramidates

Sulfoacetic acid, phosphoramidate, and phosphonamide analogs of the ACAT inhibitors, CI-999 and CI-1011 were synthesized. The structure-activity relationships of these compounds as ACAT inhibitors are described.

β-carboxy sulfonamide ACAT inhibitors

β-Carboxy sulfonyl compounds of the formula STR1 wherein R1 is aryl, R3 is hydrogen or alkyl, R3 and R4 are hydrogen or alkyl, Y is --O--, --S--, or --NR2 --, and R5 is alkyl or aryl are potent inhibitors of the enzyme acyl CoA:cholesterol acyltransferase (ACAT) and are thus useful for treating hypercholesterolemia and atherosclerosis.

Sulfonamide tetrazole ACAT inhibitors

Pharmaceutically useful compounds having ACAT inhibitory activity of the formula STR1 wherein R1 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, a heteroaromatic group or a hydrocarbon group having from 1 to 18 carbon atoms; Rsu