15190-08-6

Basic information

• Product Name: 4-Chloro-α-(dimethylamino)benzeneacetonitrile
• Synonyms: 4-Chloro-α-(dimethylamino)benzeneacetonitrile;2-(4-Chlorophenyl)-2-(dimethylamino)acetonitrile;alpha-(Dimethylamino)-4-chlorophenylacetonitrile;(4-Chlorophenyl)(dimethylamino)acetonitrile
• CAS NO: 15190-08-6
• Molecular Formula: C₁₀H₁₁ClN₂
• Molecular Weight: 194.66074
• Mol File: 15190-08-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 276.3°Cat760mmHg
• Flash Point: 120.9°C
• Appearance: /
• Density: 1.154g/cm³
• Vapor Pressure: 0.00484mmHg at 25°C
• Refractive Index: 1.548
• CAS DataBase Reference: 4-Chloro-α-(dimethylamino)benzeneacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-α-(dimethylamino)benzeneacetonitrile(15190-08-6)
• EPA Substance Registry System: 4-Chloro-α-(dimethylamino)benzeneacetonitrile(15190-08-6)

Safety Data

• Hazardous Substances Data: 15190-08-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H11ClN2/c1-13(2)10(7-12)8-3-5-9(11)6-4-8/h3-6,10H,1-2H3

Upstream product

• 4637-22-3 2-(Dimethylamino)-2-methoxyacetonitril 
• 104-88-1 4-chlorobenzaldehyde 
• 2214-82-6 Bis(dimethylamino)acetonitrile 
• 14062-80-7 N,N-dimethyl-4-chlorobenzamide 
• 122-01-0 4-chloro-benzoyl chloride 
• 7677-24-9 trimethylsilyl cyanide 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 87531-34-8 α-(p-chlorophenyl)-α-(N,N-dimethylamino)-α'-phenylazine 
• 101681-15-6 2-(4-Chloro-phenyl)-2-dimethylamino-4,4-diethoxy-butyronitrile 
• 59843-58-2 3-(4-chlorophenyl)-1H-pyrazole 
• 24314-35-0 1,4-bis(4-chlorophenyl)butane-1,4-dione 
• 128747-02-4 Methyl 4-(4-chlorobenzoyl)-4-methyl-pent-2-enoate 
• 128746-99-6 Methyl-(4-chlorobenzoyl)-4-methyl-pent-3-enoate 
• 85356-17-8 2,5-Bis(dimethylamino)-2,5-bis(4-chlorophenyl)adiponitrile 

Relevant articles and documents

One-Pot Synthesis of α-Amino Nitrile Units through Alkylative Strecker Cyanation from Formamides

In this work, we describe the one-pot synthesis of α-amino nitrile units by the concomitant addition of alkyl (or aryl) Grignard reagents and TMS cyanide through alkylative Strecker cyanation from readily available formamides. The reaction is broad in sco

Orthoamides, XXXIII.-Contributions to the Chemistry of Bis(dialkylamino)acetonitriles

Bis(dialkylamino)acetonitriles 2a-d react with acetyl chloride and antimony pentachloride to give N,N,N',N'-tetraalkylformamidinium hexachloroantimonates 5a-d.Reaction of p-nitrophenol with 2a,b affords N,N,N',N'-tetraalkylformamidinium salts 8a,b, while reaction of aromatic aldehydes 11 with compounds 2 gives aryl(dialkylamino)acetonitriles 12.Phenyl isothiocyanate reacts with the nitriles 2a-c to give 1:1 adducts for which the structure of N,N,N',N'-tetraalkylformamidinium cyano-N-(phenyl)thioformamidates 19 is proposed.N,N,N',N'-Tetraalkylformamidinium p-toluenesulfonates 30a,b have been prepared from nitriles 2a,b and methyl p-toluoenesulfonate (28).Alkylation of 2c with 28 at higher temperatures affords 1,1-dimethylpiperidinium p-toluoenesulfonate (34) and a small amount (1-piperidinyl)malonodinitrile (33).The nitrile 2a reacts with CH acidic compounds such as ethyl cyanoacetate, malonodinitrile and benzyl cyanide to form the enamines 38.