151900-41-3 Usage
Uses
Used in Chemical Synthesis:
2-fluoro-(O(6)-trimethylsilylelthyl)-2'-deoxyinosine is used as a building block in the synthesis of modified nucleic acids for various applications, such as drug development and molecular biology research. The presence of the fluoro and trimethylsilyl groups improves the stability and binding properties of the resulting nucleic acid analogues, enhancing their performance in various assays and therapeutic applications.
Used in Research and Development:
In the field of molecular biology, 2-fluoro-(O(6)-trimethylsilylelthyl)-2'-deoxyinosine serves as a research tool for studying the structure and function of nucleic acids. Its unique chemical modifications allow scientists to investigate the effects of these modifications on nucleic acid properties, such as stability, binding affinity, and reactivity. This knowledge can be applied to the design of new nucleic acid-based drugs and therapeutics.
Used in Pharmaceutical Industry:
2-fluoro-(O(6)-trimethylsilylelthyl)-2'-deoxyinosine is used as a key intermediate in the development of novel antiviral and anticancer drugs. Its unique chemical structure allows for the design of nucleic acid analogues with improved pharmacological properties, such as enhanced target binding, increased resistance to degradation, and reduced toxicity. These analogues can be further optimized for use in clinical applications, offering new treatment options for various diseases.
Used in Biotechnology Industry:
In the biotechnology sector, 2-fluoro-(O(6)-trimethylsilylelthyl)-2'-deoxyinosine is employed in the development of nucleic acid-based tools for genetic engineering and molecular diagnostics. Its unique chemical modifications enable the creation of highly specific and stable nucleic acid probes, primers, and other reagents that can be used in various biotechnological applications, such as gene expression analysis, mutation detection, and gene editing.
Overall, 2-fluoro-(O(6)-trimethylsilylelthyl)-2'-deoxyinosine is a versatile chemical compound with a wide range of applications in various industries, including chemical synthesis, research and development, pharmaceuticals, and biotechnology. Its unique chemical properties make it an invaluable tool for the advancement of nucleic acid-based technologies and therapeutics.
Check Digit Verification of cas no
The CAS Registry Mumber 151900-41-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,1,9,0 and 0 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 151900-41:
(8*1)+(7*5)+(6*1)+(5*9)+(4*0)+(3*0)+(2*4)+(1*1)=103
103 % 10 = 3
So 151900-41-3 is a valid CAS Registry Number.
151900-41-3Relevant academic research and scientific papers
DeCorte, Bart L.,Tsarouhtsis, Dimitrios,Kuchimanchi, Satyanarayan,Cooper, Monica D.,Horton, Pamela,Harris, Constance M.,Harris, Thomas M.
, p. 630 - 637 (1996)
Improved methodology has been developed for preparation of oligodeoxynucleotides bearing adducts on the N2 position of guanine in which the adduction reaction is carried out in homogeneous solution rather than while the oligonucleotide is immobilized on a solid matrix. The methodology utilizes a new synthon, 2-fluoro-O6-(trimethylsilylethyl)-2'-deoxyinosine (3). Nucleoside 3 is stable to the conditions of oligonucleotide synthesis, but the O6 protection is eliminated under very mild conditions following displacement of the 2-fluoro group by amine nucleophiles. Oligonucleotides containing 3 could be removed from the solid support by treatment with 0.1 M NaOH (8 h, rt) without disruption of 3. Reaction of the crude, partially deprotected oligonucleotide with (R)-2-amino-2-phenylethanol in homogeneous solution, followed by removal of the remaining protective groups with NH4OH (60 °C, 8 h) and then 0.1% acetic acid, gave the adducted oligonucleotide in good purity and yield. Alternatively, fully deprotected oligonucleotide containing 3 could be prepared by use of labile phenoxyacetyl-type protecting groups on the exocyclic amino groups.
Synthesis of guanosine and deoxyguanosine phosphoramidites with cross-linkable thioalkyl tethers for direct incorporation into RNA and DNA
Hou, Xiaorong,Wang, Gang,Gaffney, Barbara L.,Jones, Roger A.
experimental part, p. 1076 - 1094 (2010/09/05)
We describe the synthesis of protected phosphoramidites of deoxyriboguanosine and guanosine derivatives containing a thiopropyl tether at the guanine N2 (7a,b) for site-specific crosslinking from the minor groove of either DNA or RNA to a thiol of a prote
Stereospecific synthesis and characterization of oligodeoxyribonucleotides containing an N2-(1-carboxyethyl)-2′-deoxyguanosine
Cao, Huachuan,Jiang, Yong,Wang, Yinsheng
, p. 12123 - 12130 (2008/09/17)
Methylglyoxal is a highly reactive α-ketoaldehyde that is produced endogenously and present in the environment and foods. It can modify DNA and proteins to form advanced glycation end products (AGEs). Emerging evidence has shown that N2-(1-carb
