151920-48-8

Basic information

• Product Name: dimethyl (3-oxo-1-phenylbutyl)propanedioate
• Synonyms: Dimethyl (3-oxo-1-phenylbutyl)malonate; propanedioic acid, 2-(3-oxo-1-phenylbutyl)-, dimethyl ester
• CAS NO: 151920-48-8
• Molecular Formula: C₁₅H₁₈O₅
• Molecular Weight: 278.3004
• Mol File: 151920-48-8.mol
• Article Data: 31

Chemical Properties

• Boiling Point: 384.4°C at 760 mmHg
• Flash Point: 168.2°C
• Density: 1.145g/cm³
• Vapor Pressure: 4.1E-06mmHg at 25°C
• Refractive Index: 1.502
• CAS DataBase Reference: dimethyl (3-oxo-1-phenylbutyl)propanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl (3-oxo-1-phenylbutyl)propanedioate(151920-48-8)
• EPA Substance Registry System: dimethyl (3-oxo-1-phenylbutyl)propanedioate(151920-48-8)

Safety Data

• Hazardous Substances Data: 151920-48-8(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 124-41-4 sodium methylate 
• 1896-62-4 (E)-benzalacetone 
• 108-59-8 malonic acid dimethyl ester 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 182511-39-3 (S)-2-(3-oxo-1,3-diphenyl-propyl)-malonic acid diethyl ester 
• 182360-62-9 (S)-2-phenyl-1,1,3-propanetricarboxylic acid 1,1-dimethyl ester 
• 164931-80-0 (S)-(3-oxo-1,3-diphenyl-propyl)-malonic acid dimethyl ester 
• 5292-53-5 diethyl benzalmalonate 
• 6626-84-2 dimethyl 2-benzylidenepropanedioate 
• 844885-47-8 (S)-2-cyano-5-oxo-3-phenylhexanoic acid methyl ester 
• 917-54-4 methyllithium 
• 182360-64-1 2-((S)-2-Chlorocarbonyl-1-phenyl-ethyl)-malonic acid dimethyl ester 
• 186581-53-3 diazomethane 

Downstream Products

• 4354-90-9 (3-oxo-1-phenyl-butyl)-malonic acid 

Relevant articles and documents

Enantioselective synthesis of 2,4,5-trisubstituted tetrahydropyrans via peptide-catalyzed michael addition followed by Kishi's reductive cyclization

An enantioselective synthesis of 2,4,5-trisubstituted tetrahydropyrans has been achieved in four steps from α,β-unsaturated ketones and dimethyl malonate by peptide-catalyzed asymmetric Michael addition and diastereoselective construction of tetrahydropyr

Enantioselective Michael Addition of Malonates to Chalcone Derivatives Catalyzed by Dipeptide-derived Multifunctional Phosphonium Salts

Highly enantioselective Michael addition of malonates to enones catalyzed by dipeptide-derived multifunctional phosphonium salts has been developed. The newly established catalytic system was characterized with its wide substrate scope featured with aliphatic aldehyde-derived enones and substituted malonates. The gram scale-up synthesis of adducts can also be successfully achieved under optimal conditions with both excellent yield and enantioselectivity.

A kind of T-leucine derivative of the chiral amine compound and its preparation method and application

The invention discloses a tertiary leucine derived chiral amine compound as well as a preparation method and application thereof. The chiral amine compound contains a tert-butyl group, a primary amine, a secondary amine or a tertiary amine functional group and has the structural formula as shown in the specification; and chiral amine and salts thereof are prepared through simple preparation steps by taking common tert-leucine as the raw material to form the chiral amine compound. The chiral amine and the salts thereof can be used for the asymmetrical Michael additive reaction between alpha, beta-unsaturated ketone and a nucleophilic reagent such as nitrocarbol, malonic ester, substituted oxazolone and the like and the asymmetrical cascade reaction between the alpha, beta-unsaturated ketone and fifth-position unsaturated rhodanine, between fifth-position unsaturated hydantoin and the alpha, beta-unsaturated ketone; and the tertiary leucine derived chiral amine compound has very high catalytic activity and stereoselectivity as well as the highest diastereoselectivity of 30/1 and the highest enantioselectivity of 99%, and is wide in oligomer range.