151985-96-5Relevant academic research and scientific papers
Substituted β-alanines
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Page column 99, (2010/01/30)
The invention is directed to physiologically active compounds of general formula (I): wherein R1 is hydrogen, halogen, lower alkyl or lower alkoxy; X1, X2 and X6 independently represent N or CR2; and one of X3, X4 and X5 represents CR3 and the others independently represents N or CR2 where R2 is hydrogen, halogen, lower alkyl or lower alkoxy; and R3 represents a group —L1—(CH2)n—C(=O)—N(R4)—CH2—CH2—Y; and their prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their prodrugs. Such compounds have valuable pharmaceutical properties, in particular the ability to regulate the interaction of VCAM-1 and fibronectin with the integrin VLA-4 (à4β1).
Vicarious nucleophilic substitution of nitrobenzenes : Application of the reaction to 2-alkylnitrobenzenes
DeBoos,Milner
, p. 965 - 976 (2007/10/02)
Vicarious nucleophilic substitution (VNS) by dichloroacetate and other reagents has been applied in good yield to various ortho-substituted nitrobenzenes including 2-nitrotoluene and 2-nitro ethylbenzene. For alkyl nitrobenzenes, ease of VNS increased para ortho meta and methyl ethyl iso-propyl. Formation of chlorine-free products upon VNS by methyl dichloro- acetate suggests the involvement of radical anions.
