152009-44-4Relevant academic research and scientific papers
Preparation method of N-hydro/N-alkylated thiomorpholin-2-carboxylic acid/carboxylate compound
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Paragraph 0073; 0075; 0077, (2019/04/17)
The invention relates to a preparation method of a N-hydro/N-alkylated thiomorpholin-2-carboxylic acid/carboxylate compound. The method includes: subjecting a compound shown as formula (II) to reaction with R3COOH and alkali-metal borohydrides to obtain the N-hydro/N-alkylated thiomorpholin-2-carboxylic acid/carboxylate compound shown as formula (I), wherein R1 is selected from hydrogen and substituted or non-substituted alkyl group, R2 is selected from hydrogen and substituted or non-substituted alkyl group, and R3 is selected from hydrogen and substituted or non-substituted alkyl group. Thepreparation method of the N-hydro/N-alkylated thiomorpholin-2-carboxylic acid/carboxylate compound has a short synthetic route; the target product can be acquired just through two steps; reaction materials are easy to attain; the cost is low; the preparation method is suitable for large-scale preparation, and is high in yield, up to 34.3% to 60.7%.
N-heterocyclic derivatives as NOS inhibitors
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, (2008/06/13)
N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.
