1520156-90-4

Upstream product

• 27200-84-6 methyl triphenylphosphonium bromide 
• 130217-38-8 2-(((tert-butyldimethylsilyl)oxy)methyl)-4,5-dichlorobenzaldehyde 

Downstream Products

• 1520156-93-7 C₁₅H₂₄Cl₂O₂Si 
• 1520156-96-0 C₁₅H₂₂Cl₂O₂Si 
• 1520158-63-7 C₃₃H₅₈Cl₂O₇Si₂ 

Relevant academic research and scientific papers

NH4HF2 as a selective TBS-removal reagent for the synthesis of highly functionalized spiroketal via tandem deprotection/ spiroketalization procedure

NH4HF2 has been used for the first time to selectively remove the TBS protecting groups from diol ketone precursors in the synthesis of highly functionalized spiroketals. This method allows the synthesis of [5,6], [6,6], and [6,7] spiroketal skeletons, as well as benzannulated spiroketal with retention of acid-sensitive groups. In this way, spiroketals can be synthesized with diverse substituent groups in the skeleton or on side chains. To demonstrate the utility of this methodology, the diverse transformations of highly functionalized spiroketal 3f were also investigated.