152032-72-9Relevant academic research and scientific papers
Synthesis of 1alpha,25-dihydroxyvitamin D3-26,23-lactams (DLAMs), a novel series of 1 alpha,25-dihydroxyvitamin D3 antagonist.
Kato, Yuko,Nakano, Yusuke,Sano, Hiroko,Tanatani, Aya,Kobayashi, Hisayoshi,Shimazawa, Rumiko,Koshino, Hiroyuki,Hashimoto, Yuichi,Nagasawa, Kazuo
, p. 2579 - 2583 (2007/10/03)
Novel vitamin D(3) analogs having a lactam structure in their side chains, 1 alpha,25-dihydroxyvitamin D(3)-26,23-lactams (DLAMs), were designed based on the principle of regulation of the folding of helix-12 in the vitamin D nuclear receptor (VDR). The n
Novel heteroatom-containing vitamin D3 analogs: Efficient synthesis of 1α,25-dihydroxyvitamin D3-26,23-lactam
Kato, Yuko,Hashimoto, Yuichi,Nagasawa, Kazuo
, p. 488 - 499 (2007/10/03)
Vitamin D3 and its synthetic analogs are promising compounds for controlling various types of cell differentiation. In this article, we describe the synthesis of novel vitamin D3 analogs containing heteroatoms in their side chains - so-called vitamin D3 lactam analogs - via 1,3-dipolar cycloaddition reaction as a key step.
