152035-84-2Relevant academic research and scientific papers
Synthesis of Acyclic Polyol Derivatives via Enzyme-Mediated Aldol Reaction
Matsumoto, Kazutsugu,Shimagaki, Masayuki,Nakata, Tadashi,Oishi, Takeshi
, p. 4935 - 4938 (2007/10/02)
Enzyme-mediated stereoselective aldol reaction between dihydroxyacetone phosphate (DHAP, 1) and (2R,4R)-6-benzyloxy-2,4-dimethoxyhexanal (8) was catalyzed by rabbit muscle aldolase (RAMA) to generate (3S,4R,5R,7R)-trihydroxyketone 12, which could be easily transformed to the masked polyhydroxylated compound 15 corresponding to the C-9-C-16 segment of pentamycin (6).
