1520814-76-9

Upstream product

• 615-42-9 1,2-Diiodobenzene 
• 91-60-1 2-Naphthalenethiol 

Downstream Products

• 205-43-6 Benzo[b]naphtho[1,2-d]thiophene 

Relevant academic research and scientific papers

Reaction method of thiophenol and O-diiodobenzene

The invention discloses a reaction method of thiophenol and o-diiodobenzene. The method comprises the following steps: taking thiophenol and o-diiodobenzene as substrates, reacting in a solvent in the presence of a metal hydride, and completing the reaction of thiophenol and o-diiodobenzene to obtain o-iodobenzene sulfide. Under the action of NaH, o-diiodobenzene and thiophenol are subjected to a nucleophilic reaction to generate an o-iodobenzene sulfide product. According to the method, C-S bond coupling is completed without transition metal participation, operation is easy and convenient, and the problems of metal reagent residues, pollution and the like are solved; meanwhile, compared with an existing precursor, o-diiodobenzene is low in price and convenient to prepare, and has better atom economy; and an iodine exists at the ortho-position of the generated product phenyl sulfide, other conversions can be conveniently carried out to obtain various 1, 2-substituted benzene, and particularly, the excellent yield can be obtained by only needing 3 equivalents of metal hydride.

Preparation method of phenyl sulfide compound

The invention discloses a preparation method of a phenyl sulfide compound, which comprises the following steps: by taking thiophenol and o-diiodobenzene as substrates, reacting in a solvent in the presence of a metal hydride to obtain iodine-containing phenyl sulfide; the iodine-containing phenyl sulfide can be subjected to intramolecular reaction to obtain a phenyl sulfide compound; or the iodine-containing phenyl sulfide can react with other raw materials to obtain the phenyl sulfide compound. The ortho-iodine compound prepared by the invention has great application value, can be further widely converted, can be subjected to coupling reaction with phenylboronic acid, thiophenol, phenylacetylene and the like under the catalysis of Pd to prepare various 2-substituted thiophenol, and has important significance in material science and pharmaceutical synthesis.

Copper-catalyzed selective single arylsulfanylation of aryl diiodides with aryl thiols

Selective single arylsulfanylation reactions of aryl diiodides with aryl or hetaryl thiols to give a broad array of iodine-functionalized sulfides were developed. Further elaboration of the iodine-containing products to provide a variety of aryl and hetaryl sulfides through coupling reactions was also demonstrated. Georg Thieme Verlag Stuttgart, New York.