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1521197-43-2

C16H15ClN4O is a pyrimidine-based organic molecule with a molecular weight of 308.77 g/mol. It consists of 16 carbon atoms, 15 hydrogen atoms, 1 chlorine atom, 4 nitrogen atoms, and 1 oxygen atom. The presence of these diverse atoms suggests its potential for various biological and chemical functions.
Used in Pharmaceutical Industry:
C16H15ClN4O is used as a pharmaceutical compound for its potential biological activity. The specific arrangement of its atoms and the presence of nitrogen and oxygen atoms may contribute to its interaction with biological targets, making it a candidate for drug development.
Used in Chemical Research:
C16H15ClN4O is used as a research molecule in chemical studies. Its unique composition and the presence of chlorine, nitrogen, and oxygen atoms make it an interesting subject for exploring chemical reactions and properties.
Used in Material Science:
C16H15ClN4O is used as a component in the development of new materials. The diverse atoms in its structure may contribute to the creation of materials with specific properties, such as conductivity, stability, or reactivity.
Note: The exact applications and uses of C16H15ClN4O would require further analysis and testing to determine its specific properties and potential in various industries.

1521197-43-2

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  • 2-chloro-11-cyclopentyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one

    Cas No: 1521197-43-2

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  • 2-Chloro-11-cyclopentyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one

    Cas No: 1521197-43-2

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1521197-43-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1521197-43-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,5,2,1,1,9 and 7 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1521197-43:
(9*1)+(8*5)+(7*2)+(6*1)+(5*1)+(4*9)+(3*7)+(2*4)+(1*3)=142
142 % 10 = 2
So 1521197-43-2 is a valid CAS Registry Number.

1521197-43-2Downstream Products

1521197-43-2Relevant articles and documents

PYRIMIDO-DIAZEPINONE COMPOUNDS AND METHODS OF TREATING DISORDERS

-

, (2016/02/16)

The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), LRKK2, EphA2, polo kinase 1,2,3, or 4, Ack1, Ack2, Abl, DCAMKL1, ABL1, Abl mutants, DCAMKL2, ARK5, BRK,

Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones

Deng, Xianming,Elkins, Jonathan M.,Zhang, Jinwei,Yang, Qingkai,Erazo, Tatiana,Gomez, Nestor,Choi, Hwan Geun,Wang, Jinhua,Dzamko, Nicolas,Lee, Jiing-Dwan,Sim, Taebo,Kim, Namdoo,Alessi, Dario R.,Lizcano, Jose M.,Knapp, Stefan,Gray, Nathanael S.

, p. 758 - 767 (2013/12/04)

The benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-one core was discovered as a novel ERK5 (also known as MAPK7 and BMK1) inhibitor scaffold, previously. Further structure-activity relationship studies of this scaffold led to the discovery of ERK5-IN-1 (26) as the most selective and potent ERK5 inhibitor reported to date. 26 potently inhibits ERK5 biochemically with an IC 50 of 0.162 ± 0.006 μM and in cells with a cellular EC 50 for inhibiting epidermal growth factor induced ERK5 autophosphorylation of 0.09 ± 0.03 μM. Furthermore, 26 displays excellent selectivity over other kinases with a KINOMEscan selectivity score (S10) of 0.007, and exhibits exceptional bioavailability (F%) of 90% in mice. 26 will serve as a valuable tool compound to investigate the ERK5 signaling pathway and as a starting point for developing an ERK5 directed therapeutic agent.

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