15212-09-6

Basic information

• Product Name: 4-hydroxy-3-methoxybenz-[14C]-aldehyde
• Synonyms: 4-hydroxy-3-methoxybenz-[14C]-aldehyde
• CAS NO: 15212-09-6
• Molecular Weight: 154.139
• Mol File: 15212-09-6.mol

Chemical Properties

• CAS DataBase Reference: 4-hydroxy-3-methoxybenz-[14C]-aldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-3-methoxybenz-[14C]-aldehyde(15212-09-6)
• EPA Substance Registry System: 4-hydroxy-3-methoxybenz-[14C]-aldehyde(15212-09-6)

Safety Data

• Hazardous Substances Data: 15212-09-6(Hazardous Substances Data)

Upstream product

• 61853-17-6 <14C>N,N-dimethylformamide 
• 111047-58-6 (+/-)-1-bromo-4-(1-ethoxyethyl)-3-methoxybenzene 

Relevant articles and documents

Labelled compounds of interest as antitumour agents - VII(I) [2H]- and [14C]-Curcumin

Curcumin (E,E-1,7-di(4-hydroxy-3-methoxyphenyl)-3-hydroxyhepta-1,3,6-trien-5-one) is an investigational cancer chemopreventive agent. Lithium-bromine exchange of 1-bromo-4-(1-ethoxyethyl)-3-methoxybenzene with butyl lithium, quench with O2HCNMe2 and acidic work-up gave 4-hydroxy-3-methoxybenz-[2H]-aldehyde ([2H]-vanillin) in 27% yield (based on O2HCNMe2). Condensation with pentane-2,4-dione then gave E,E-1,7-di(4-hydroxy-3-methoxyphenyl)-3-hydroxy-1,7-di-[2H]-hepta-1,3,6-trien-5-one ([2H2]-curcumin). Adaptation of the procedures and use of OH14CNMe2 provided [14C]-curcumin (specific radioactivity 12.7 MBq mmol-1) via [14C]-vanillin.