152121-41-0

Usage

Uses

1. Used in Pharmaceutical Industry:
1-(4-Fluorophenyl)-2-(4-pyridinyl)-1,2-ethanedione is used as a chemical intermediate for the preparation of substituted imidazoles, which are important in the development of pharmaceutical compounds. The application reason is that these substituted imidazoles can exhibit a range of biological activities, making them valuable in the creation of new drugs for various medical conditions.
2. Used in Chemical Synthesis:
In the field of chemical synthesis, 1-(4-Fluorophenyl)-2-(4-pyridinyl)-1,2-ethanedione serves as a key building block for the synthesis of more complex organic molecules. The application reason is its unique structure, which allows for further functionalization and the creation of a diverse array of chemical products with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

InChI:InChI=1/C13H8FNO2/c14-11-3-1-9(2-4-11)12(16)13(17)10-5-7-15-8-6-10/h1-8H

Upstream product

• 6576-05-2 1-(4-fluorophenyl)-2-(4-pyridyl)ethanone 
• 115858-98-5 1-(4-fluorophenyl)-2-(pyridin-4-yl)-2-ethanone 
• 152121-40-9 1-(4-fluorophenyl)-2-pyridin-4-ylethane-1,2-diol 
• 451-46-7 4-fluorobenzoic acid ethyl ester 
• 108-89-4 picoline 

Downstream Products

• 181630-93-3 4-(4-Fluorophenyl)-5-(pyridin-4-yl)-1H-imidazole 
• 1207532-00-0 2-(4-fluorophenyl)-3-(pyridin-4-yl)pyrido[2,3-b]pyrazine 
• 1207531-96-1 3-(4-fluorophenyl)-2-(pyridin-4-yl)pyrido[2,3-b]pyrazine 
• 1207532-01-1 2-(4-fluorophenyl)-3-(pyridin-4-yl)pyrido[4,3-b]pyrazine 
• 1207531-97-2 3-(4-fluorophenyl)-2-(pyridin-4-yl)pyrido[3,4-b]pyrazine 
• 1207531-65-4 2-(4-fluorophenyl)-3-(pyridin-4-yl)quinoxaline 
• 1191272-27-1 3-(4-fluorophenyl)-6-methoxy-2-(pyridin-4-yl)quinoxaline 
• 1207531-68-7 2-(4-fluorophenyl)-6-methoxy-3-(pyridin-4-yl)quinoxaline 

Relevant academic research and scientific papers

The anion of 3-methyl-2-pyridin-4-yl-1,3-oxazine

n-Butyllithium at -78°C readily abstracts the methine proton from the title compound. The anion reacts efficiently with a range of electrophiles to provide 4-pyridyl ketones upon acid hydrolysis.

Pyridinylquinoxalines and pyridinylpyridopyrazines as lead compounds for novel p38α mitogen-activated protein kinase inhibitors

Various substituted 2(3)-(4-fluorophenyl)-3(2)-(pyridin-4-yl)quinoxalines and 2(3)-(4-fluorophenyl)-3(2)-(pyridin-4-yl)pyridopyrazines were synthesized as novel p38α MAP kinase inhibitors via different short synthetic strategies with high variation possibilities. The formation of the quinoxaline/ pyridopyrazine core was achieved from α-diketones and o-phenylenediamines/ α-diaminopyridines under microwave irradiation. Introduction of an amino moiety at the pyridine C2 position of the 2(3)-(4-fluorophenyl)-3(2)-(pyridin-4- yl)quinoxalines led to compounds showing potent enzyme inhibition down to the double-digit nanomolar range (6f; IC50 = 81 nM). Replacement of the quinoxaline core with pyrido[2,3-b]pyrazine gave compound 9e with superior p38α MAP kinase inhibition (IC50= 38 nM).

Role of the hydrogen bonding heteroatom-lys53 interaction between the p38r mitogen-activated protein (map) kinase and pyridinyl-substituted 5-membered heterocyclic ring inhibitors

In the framework of investigating the role of heteroatoms in pyridinyl-substituted 5-membered (hetero)cycles as potential p38α MAP kinase inhibitor scaffolds, cyclopentene, pyrrole, furan, and imidazole analogues were synthesized and tested with respect t

PYRAZINE DERIVATIVES USEFUL AS ADENOSINE RECEPTOR ANTAGONISTS

The present invention provides a compound of formula (I) wherein: A represents an optionally substituted monocyclic or polycyclic aryl or heteroaryl group B represents an optionally substituted monocyclic nitrogen-containing heteroaryl group ; and either a) R1 and R2 represent hydrogen or specified substituents, or b) R2, R1 and the -NH- group to which R1 is attached, form a moiety selected from the moiety of formulae (IIa) and (IIb): (IIa) These compounds are useful as antagonists of the A2B receptor, for instance in the treatment of asthma.

Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents

Several analogs of 2,3-diaryl pyrroles were synthesized and evaluated as inhibitors of Eimeria tenella cGMP-dependent protein kinase and in in vivo anticoccidial assays. A 4-fluorophenyl group enhances both in vitro and in vivo activities. The most potent

Imidazolyl-cyclic acetals

Compounds of formula (I) are described in which R1is optionally substituted heteroaryl; R2is optionally substituted aryl or optionally substituted heteroaryl; R3is a group —L1—R7or —L2—Rsu

2-substituted imidazoles useful in the treatment of inflammatory diseases

This invention relates to substituted imidazoles of Formula I pharmaceutical compositions containing them, methods of using them and intermediates useful in their manufacture. The compounds of the invention modulate the production of a number of inflammat

Substituted imidazoles useful in the treatment of inflammatory disease

This invention relates to a series of substituted imidazoles of Formula I STR1 pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention inhibit the production of a number of inflammatory cytok