1521267-00-4Relevant academic research and scientific papers
A concise synthesis of (-)-lasonolide A
Trost, Barry M.,Stivala, Craig E.,Hull, Kami L.,Huang, Audris,Fandrick, Daniel R.
, p. 88 - 91 (2014)
Lasonolide A is a novel polyketide displaying potent anticancer activity across a broad range of cancer cell lines. Here, an enantioselective convergent total synthesis of the (-)-lasonolide A in 16 longest linear and 34 total steps is described. This approach significantly reduces the step count compared to other known syntheses. The synthetic strategy utilizes alkyne-bearing substrates as core building blocks and is highlighted by stitching together two similarly complex halves via a key Ru-catalyzed alkene-alkyne coupling and macrolactionization.
