152127-34-9

Usage

Uses

Used in Pharmaceutical Synthesis:
PHENYL-(1-PYRIDIN-4-YL-ETHYL)-AMINE is used as a key intermediate in the synthesis of pharmaceutical drugs for its ability to contribute to the formation of complex molecular structures that possess therapeutic properties.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, PHENYL-(1-PYRIDIN-4-YL-ETHYL)-AMINE is used as a building block for the development of new drugs with biological activity, leveraging its unique structure to create compounds that can interact with biological targets.
Used in Organic Compounds Synthesis:
PHENYL-(1-PYRIDIN-4-YL-ETHYL)-AMINE is utilized as a reactant in the synthesis of various organic compounds, where its aromatic amine structure can be incorporated into a wide range of chemical products.
Used in Industrial Chemical Production:
PHENYL-(1-PYRIDIN-4-YL-ETHYL)-AMINE is also used as a component in the production of industrial chemicals, where its specific chemical properties may be harnessed for specific applications in various industries.

Upstream product

• 23389-75-5 rac-1-(pyridin-4-yl)ethanol 
• 62-53-3 aniline 

Relevant academic research and scientific papers

Reusable Co-nanoparticles for general and selectiveN-alkylation of amines and ammonia with alcohols

A general cobalt-catalyzedN-alkylation of amines with alcohols by borrowing hydrogen methodology to prepare different kinds of amines is reported. The optimal catalyst for this transformation is prepared by pyrolysis of a specific templated material, which is generatedin situby mixing cobalt salts, nitrogen ligands and colloidal silica, and subsequent removal of silica. Applying this novel Co-nanoparticle-based material, >100 primary, secondary, and tertiary amines includingN-methylamines and selected drug molecules were conveniently prepared starting from inexpensive and easily accessible alcohols and amines or ammonia.

Mechanistic Studies of Hydride Transfer to Imines from a Highly Active and Chemoselective Manganate Catalyst

We introduce a highly active and chemoselective manganese catalyst for the hydrogenation of imines. The catalyst has a large scope, can reduce aldimines and ketimines, and tolerates a variety of functional groups, among them hydrogenation sensitive examples such as an olefin, a ketone, nitriles, nitro groups, and an aryl iodo substituent or a benzyl ether. We could investigate the transfer step between imines and the hydride complex in detail. We found that double deprotonation of the ligand is essential and excess base does not lead to a higher rate in the transfer step. We identified the actual hydrogenation catalyst as a K-Mn-bimetallic species and could obtain a structure of the K-Mn complex formed after hydride transfer by X-ray analysis. NMR experiments indicate that the hydride transfer is a well-defined reaction, which is first order in imine, first order in the bimetallic (K-Mn) hydride, and independent in rate from the concentration of the potassium base. We propose an outer-sphere mechanism in which protons do not seem to be involved in the rate-determining step, leading to a transiently negatively charged nitrogen atom in the substrate which reacts rapidly with HOtBu (2-methylpropan-2-ol) to produce the amine. This is based on several observations, such as no dependency of the reaction rate on the HOtBu concentration, no observable manganese amide complex, and a high reaction constant in a conducted Hammett study. Furthermore, hydrogen transfer of the catalytic cycle was experimentally probed and monitored by NMR with subsequent quantitative regeneration of the catalyst by H2.