15213-01-1Relevant academic research and scientific papers
Synthesis, antifungal activity and structure-activity relationships of novel 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid amides
Du, Shijie,Tian, Zaimin,Yang, Dongyan,Li, Xiuyun,Li, Hong,Jia, Changqing,Che, Chuanliang,Wang, Mian,Qin, Zhaohai
, p. 8395 - 8408 (2015/05/20)
A series of novel 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid amides were synthesized and their activities were tested against seven phytopathogenic fungi by an in vitro mycelia growth inhibition assay. Most of them displayed moderate to excellent activities. Among them N-(2-(5-bromo-1H-indazol-1-yl)phenyl)-3-(difluoro-methyl)-1-methyl-1H-pyrazole-4-carboxamide (9m) exhibited higher antifungal activity against the seven phytopathogenic fungi than boscalid. Topomer CoMFA was employed to develop a three-dimensional quantitative structure-activity relationship model for the compounds. In molecular docking, the carbonyl oxygen atom of 9m could form hydrogen bonds towards the hydroxyl of TYR58 and TRP173 on SDH.
3-AZABICYCLO [3.1.0] HEXANE DERIVATIVES AS VANILLOID RECEPTOR LIGANDS
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Page/Page column 44, (2009/08/16)
The present invention relates to 3-azabicyclo[3.1.0]hexane derivatives, which are useful as vanilloid receptor (VR) ligands, methods of treating diseases, conditions and/or disorders modulated by vanilloid receptors with them, and processes for preparing them.
Coumarin derivatives
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, (2008/06/13)
Coumarin compounds of the formula: STR1 in which R represents an alkyl group containing 1 to 5 carbon atoms, either unsubstituted or substituted by a non-ionic and non-chromophoric group, one of the substituents R1 or R2 represents a triazole radical, and the other represents hydrogen or a halogen, or an alkyl group containing from 1 to 3 carbon atoms, the triazole radical being unsubstituted or substituted by one or two substituents consisting of an alkyl group containing from 1 to 3 carbon atoms or an aryl group; processes for their preparation and their use as fluorescent brightening agents for polyester fibres.
