152141-78-1

Upstream product

• 88445-11-8 (R)-4,4,4-trifluoro-3-phenyl-3-hydroxybutyne 
• 434-45-7 2,2,2-Trifluoroacetophenone 
• 16753-62-1 methylvinyldimethoxysilane 
• 141946-97-6 (+)-1,1,1-trifluoro-2-phenylbut-3-yn-2-yl acetate 

Downstream Products

• 52356-09-9 3-Phenyl-3-hydroxy-4.4.4-trifluoro-buttersaeure 
• 17257-70-4 (R)-α-hydroxy-α-trifluoromethylphenyl acetic acid 
• 151990-50-0 (2R,3S)-1,1,1-trifluoro-2-phenyl-3,4-epoxybutane-2-ol 

Relevant academic research and scientific papers

Catalytic enantioselective alkenylation and phenylation of trifluoromethyl ketones

Catalytic enantioselective alkenylation and phenylation of trifluoromethyl ketones are described. High enantioselectivity (up to 84% ee) was produced in an alkenylation of aryl trifluoromethyl ketones using a CuF-DTBM-SEGPHOS complex as the catalyst (5-10

Characterization of a novel esterase isolated from intertidal flat metagenome and its tertiary alcohols synthesis

A gene coding for an esterase (EstEH112) was isolated from metagenome originated from Korean intertidal flat sediment. The putative esterase gene encoded a 340 amino acids protein with characteristic residues of lipolytic enzymes such as a conserved pentapeptide (GXSXG), the typical catalytic S-D-H triad, and a GGG(A)X-motif in the oxyanion hole near the active site similar to the hormone sensitive lipase (HSL) family. p-Nitrophenyl butyrate was the best substrate for the enzyme among the other p-nitrophenyl esters investigated. The apparent optimal temperature and pH for EstEH112 was 35°C and at pH 8.0, respectively. EstEH112 efficiently catalyzed the hydrolysis of various large tertiary alcohol esters. These characteristics of EstEH112 make it a potential candidate for application in biocatalysis.

The synthesis of (R)-γ-phenyl-γ-(trifluoromethyl)-butyrolactone and (2R,3S)-1,1,1-trifluoro-2-methoxy-2-phenyl-3,4-epoxybutane in homochiral forms

(R)-γ-Phenyl-γ-(trifluoromethyl)-butyrolactone (1) and (2R,3S)-1,1,1-trifluoro-2-methoxy-2-phenyl-3,4-epoxybutane (2) have been prepared in high optical purity from the tertiary (S)-(3)-acetate which was resolved using the lipase from Candida cylindracea.