152170-30-4

Basic information

• Product Name: 2-chloro-Thiazolo[4,5-b]pyridine
• Synonyms: Thiazolo[4,5-b]pyridine, 2-chloro-;2-chloro-Thiazolo[4,5-b]pyridine;2-Chlorthiazolo[4,5-b]pyridine;2-chlorothiazolo[4
• CAS NO: 152170-30-4
• Molecular Formula: C₆H₃ClN₂S
• Molecular Weight: 170.623
• Product Categories: Heterocycle-Pyridine series
• Mol File: 152170-30-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 263.5 °C at 760 mmHg
• Flash Point: 113.1 °C
• Appearance: /
• Density: 1.531 g/cm³
• Vapor Pressure: 0.0168mmHg at 25°C
• Refractive Index: 1.71
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.95±0.50(Predicted)
• CAS DataBase Reference: 2-chloro-Thiazolo[4,5-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-Thiazolo[4,5-b]pyridine(152170-30-4)
• EPA Substance Registry System: 2-chloro-Thiazolo[4,5-b]pyridine(152170-30-4)

Safety Data

• Hazardous Substances Data: 152170-30-4(Hazardous Substances Data)

Usage

General Description

2-chloro-Thiazolo[4,5-b]pyridine is a type of organic compound that belongs to the group of Thiazolopyridines. It is formed by the fusion of thiazole and pyridine, two types of heterocyclic compounds. The featuring of chlorine substituent at the second position of this molecule indicates its name as '2-chloro'. While it does not naturally occur, it can be synthesized in the laboratory under controlled conditions. The possible applications and effects on human health and environment would depend on the specific nature and characteristics of the molecules it is combined with in chemical reactions.

InChI:InChI=1/C6H3ClN2S/c7-6-9-5-4(10-6)2-1-3-8-5/h1-3H

Upstream product

• 152170-29-1 thiazolo<4,5-b>pyridine-2(3H)-one 
• 99158-61-9 2-mercaptothiazolo[4,5-b]pyridine 
• 15128-82-2 3-hydroxy-2-nitropyridine 
• 152170-28-0 2-amino-3-dimethylcarbamoylthiopyridine 
• 152170-26-8 N,N-dimethyl-1-[(2-nitropyridin-3-yl)oxy]methanethioamide 
• 152170-27-9 N,N-dimethyl-1-[(2-nitropyridin-3-yl)sulfanyl]formamide 
• 99158-61-9 thiazolo[4,5-b]pyridine-2(3H)-thione 

Downstream Products

• 1190927-35-5 2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethanol 

Relevant articles and documents

BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS

Disclosed are compounds of Formula (I) to (VIII): (I) (II) (III) (IV) (V) (VI) (VII) (VIII); or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a bicyclic heteroaryl group substituted with zero to 3 R3a; and R1, R2, R3a, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.

Synthesis and structure-activity relationships of 2-(1,4′-bipiperidin-1′-yl)thiazolopyridine as H3 receptor antagonists

A series of 2-(1,4′-bipiperidine-1′-yl)thiazolopyridines was synthesized and evaluated as a new lead of non-imidazole histamine H3 receptor antagonists. Introduction of diversity at the 6-position of the pyridine ring was designed to enhance in vitro potency and decrease hERG activity. The structure-activity relationships for these new thiazolopyridine antagonists are discussed.

PREPARATION AND USE OF BIPHENYL-4-YL-CARBONYLAMINO ACID DERIVATIVES FOR THE TREATMENT OF OBESITY

This invention relates to certain biphenyl-4-yl carbonylamino acid compounds, compositions, and methods for treating or preventing obesity and related diseases.