152191-51-0

Basic information

• Product Name: N-(3-(3-piperidinomethylphenoxy)propyl)-4-piperidinocarbonylpentacyclo(4.2.0.0(2,5).0(3,8).0(4,7))octane carboxamide
• Synonyms: N-(3-(3-piperidinomethylphenoxy)propyl)-4-piperidinocarbonylpentacyclo(4.2.0.0(2,5).0(3,8).0(4,7))octane carboxamide
• CAS NO: 152191-51-0
• Molecular Formula: C30H39 N3 O3
• Molecular Weight: 489.65
• Mol File: 152191-51-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 708.8°Cat760mmHg
• Flash Point: 382.5°C
• Appearance: /
• Density: 1.329g/cm³
• Vapor Pressure: 6.13E-20mmHg at 25°C
• Refractive Index: 1.66
• PKA: 15.68±0.40(Predicted)
• CAS DataBase Reference: N-(3-(3-piperidinomethylphenoxy)propyl)-4-piperidinocarbonylpentacyclo(4.2.0.0(2,5).0(3,8).0(4,7))octane carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-(3-piperidinomethylphenoxy)propyl)-4-piperidinocarbonylpentacyclo(4.2.0.0(2,5).0(3,8).0(4,7))octane carboxamide(152191-51-0)
• EPA Substance Registry System: N-(3-(3-piperidinomethylphenoxy)propyl)-4-piperidinocarbonylpentacyclo(4.2.0.0(2,5).0(3,8).0(4,7))octane carboxamide(152191-51-0)

Safety Data

• Hazardous Substances Data: 152191-51-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C30H39N3O3/c34-27(31-11-8-16-36-20-10-7-9-19(17-20)18-32-12-3-1-4-13-32)29-21-24-22(29)26-23(29)25(21)30(24,26)28(35)33-14-5-2-6-15-33/h7,9-10,17,21-26H,1-6,8,11-16,18H2,(H,31,34)

Upstream product

• 73278-98-5 N-<3-<3-(1-piperidinylmethyl)phenoxy>propyl>amine 

Relevant articles and documents

Antiulcer agents. III. Synthesis and antiulcer activity of N-[3-(3- piperidinomethylphenoxy)propyl]pentacyclo[4.2.0.02,5.03,8.04,7]- octane carboxamides and related compounds

The synthesis and antiulcer activity of highly strained cage compounds such as pentacyclo[4.2.0.02,5.03,8.04,7]-octane (cubane), pentacyclo[4.3.0.02,5.03,8.04,7]nonane (homocubane) and pentacyclo[5.3.0.02,4.03,6.05,8]decane are described. Of the compounds obtained, N-[3-(3-piperidinomethylphenoxy)propyl]-4- piperidinocarbonylpentacyclo[4.2.0.02,5.03,8.04,7]octane carboxamide (26a) and N-[3'-(3'-piperidinomethylphenoxy)propyl]-1-bromo-9,9- ethylenedioxypentacyclo[4.3.0.02,5.03,8.04,7]nonane]-4-carboxamide (26q) showed more potent antiulcer activity with very good cytoprotective ability in the HCl·ethanol-treated rat model. Compounds 26a and 26q exhibited H2-receptor antagonist potency (in vitro) comparable to that of ranitidine, but did not inhibit histamine-stimulated acid secretion (in vivo) in the gastric fistula rat model, when orally administered in the dose range at which antiulcer and cytoprotective activities were seen. The structure- activity relationships are discussed.